Abstract:
:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a complex function of LSP1 in regulating leukocyte recruitment to inflamed sites. Based on current evidence, we propose that the levels of LSP1 on the cytoskeleton and the type of integrin involved are some of the critical elements which affect LSP1 function in modulating the threshold for transmigration.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Jongstra-Bilen J,Jongstra Jdoi
10.1385/IR:35:1:65subject
Has Abstractpub_date
2006-01-01 00:00:00pages
65-74issue
1-2eissn
0257-277Xissn
1559-0755pii
IR:35:1:65journal_volume
35pub_type
杂志文章,评审abstract::The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
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