Abstract：
:Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It is conceivable that autoimmune memory would be particularly harmful since memory cells would constantly "remember" and attack the body's healthy tissues. It is even more detrimental given the resistance of memory T cells to immunomodulatory therapies. In this review, we focus on self-antigen-reactive CD(+) effector memory T (TEM) cells, surveying the evidence for the role of the T(EM) compartment in autoimmune pathogenesis. We will also discuss the role of T(EM) cells in chronic and acute infectious disease settings and how they compare to their counterparts in autoimmune diseases. With their long-lasting potency, the autoimmune T(EM) cells could also play a critical role in anti-tumor immunity, which may be largely based on their reactivity to self-antigens. Therefore, although autoimmune T(EM) cells are "bad" due to their role in relentless perpetration of tissue damage in autoimmune disease settings, they are unlikely a by-product of industrial development along the modern surge of autoimmune disease prevalence. Rather, they may be a product of evolution for their "good" in clearing damaged host cells in chronic infections and malignant cells in cancer settings.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Devarajan P,Chen Zdoi
10.1007/s12026-013-8448-1subject
Has Abstractpub_date
2013-12-01 00:00:00pages
12-22issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
57pub_type
杂志文章,评审abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...
journal_title：Immunologic research
pub_type： 传,历史文章,杂志文章,评审
doi：10.1007/s12026-014-8506-3
更新日期：2014-05-01 00:00:00
abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09164-2
更新日期：2020-11-03 00:00:00
abstract：:It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initial...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:33:2:135
更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-019-9066-3
更新日期：2019-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9051-2
更新日期：2018-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02788754
更新日期：1998-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8276-8
更新日期：2012-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09115-x
更新日期：2020-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8086-1
更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-020-09119-7
更新日期：2020-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786433
更新日期：1998-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918171
更新日期：1995-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8345-z
更新日期：2013-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:219
更新日期：2003-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-8010-0
更新日期：2008-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8370-y
更新日期：2013-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:21:2-3:129
更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8995-6
更新日期：2018-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8913-3
更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8768-4
更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8737-y
更新日期：2016-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02919697
更新日期：1991-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-011-8253-7
更新日期：2011-12-01 00:00:00
abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8982-3
更新日期：2018-02-01 00:00:00
