Abstract:
:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicle, but also leads to secretion of anti-dsDNA autoantibodies. Intriguingly, if T regulatory cells are provided along with T helper cells, the antibody response of anti-dsDNA B cells is diminished. We have also found that T-independent stimulation with CpG oligodeoxynucleotides leads to the proliferation and enhanced recovery of antidsDNA B cells in vitro. These data suggest that control of anti-dsDNA antibody production may rely on elements from both the innate and adaptive arms of the immune system.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Fields ML,Seo SJ,Nish SA,Tsai JH,Caton AJ,Erikson Jdoi
10.1385/IR:27:2-3:219subject
Has Abstractpub_date
2003-01-01 00:00:00pages
219-34issue
2-3eissn
0257-277Xissn
1559-0755pii
IR:27:2-3:219journal_volume
27pub_type
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