Abstract：
:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung structural cells and the resident and migratory immune cells in the lung. Epithelial cells play a crucial role in allergic sensitization by directly influencing dendritic cells induction of tolerant or effector T cells and production of type 2 cytokines by innate immune cells. During chronic disease, the bronchial epithelium, stroma, and smooth muscle become structurally and functionally altered, contributing to the perpetuation of tissue remodeling. Thus, targeting tissue-driven pathology in addition to inflammation may increase the effectiveness of asthma treatment.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Ramakrishna L,de Vries VC,Curotto de Lafaille MAdoi
10.1007/s12026-012-8296-4subject
Has Abstractpub_date
2012-09-01 00:00:00pages
213-28issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
53pub_type
杂志文章,评审abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...
journal_title：Immunologic research
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2010-03-01 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2011-08-01 00:00:00
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journal_title：Immunologic research
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更新日期：2020-11-03 00:00:00
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更新日期：2008-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8867-x
更新日期：2017-02-01 00:00:00
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journal_title：Immunologic research
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更新日期：1992-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2019-02-01 00:00:00
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更新日期：2013-03-01 00:00:00
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更新日期：2016-08-01 00:00:00
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更新日期：2017-08-01 00:00:00
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更新日期：1986-01-01 00:00:00
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更新日期：2003-01-01 00:00:00
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更新日期：2009-12-01 00:00:00
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更新日期：2019-12-01 00:00:00
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