Abstract：
:The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung disease. Using autoantigen array analysis, we demonstrated that COPD patients produce autoantibodies reactive to a broad spectrum of self-antigens. Further, the level and reactivities of these antibodies, or autoantibody profile, correlated with disease phenotype. Patients with emphysema produced autoantibodies of higher titer and reactive to an increased number of array antigens. Strikingly, the autoantibody reactivities observed in emphysema were increased over those detected in rheumatoid arthritis patients, and included similar reactivities to those associated with lupus. These findings raise the possibility that autoantibody profiles may be used to determine COPD risk, as well as provide a diagnostic and prognostic tool. They shed light on the heterogeneity of autoantibody reactivities associated with COPD phenotype and could be of use in the personalization of medical treatment, including determining and monitoring therapeutic interventions.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Packard TA,Li QZ,Cosgrove GP,Bowler RP,Cambier JCdoi
10.1007/s12026-012-8347-xsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
48-57issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
55pub_type
杂志文章abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8264-z
更新日期：2012-06-01 00:00:00
abstract：:The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8130-9
更新日期：2010-03-01 00:00:00
abstract：:The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8576-2
更新日期：2014-12-01 00:00:00
abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919739
更新日期：1991-01-01 00:00:00
abstract：:Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-015-8718-1
更新日期：2015-12-01 00:00:00
abstract：:CD27 is a tumor necrosis factor (TNF) receptor family member whose expression is limited to cells of the lymphoid lineage. Constitutively expressed on T lymphocytes, it is a costimulatory molecule for a regulatory subset. Induced on B lymphocytes after antigenic challenge, it is a marker of memory cells. CD70, CD27 li...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:1:23
更新日期：2000-01-01 00:00:00
abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09123-x
更新日期：2020-02-01 00:00:00
abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...
journal_title：Immunologic research
pub_type： 传,历史文章,杂志文章,评审
doi：10.1007/s12026-014-8506-3
更新日期：2014-05-01 00:00:00
abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8683-8
更新日期：2016-04-01 00:00:00
abstract：:Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and m...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8980-5
更新日期：2018-02-01 00:00:00
abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8867-x
更新日期：2017-02-01 00:00:00
abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919132
更新日期：1992-01-01 00:00:00
abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8457-0
更新日期：2013-12-01 00:00:00
abstract：:Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8562-8
更新日期：2015-03-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8869-8
更新日期：2016-12-01 00:00:00
abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918496
更新日期：1995-01-01 00:00:00
abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918253
更新日期：1996-01-01 00:00:00
abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786443
更新日期：1998-01-01 00:00:00
abstract：:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cy...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8976-1
更新日期：2018-02-01 00:00:00
abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8587-z
更新日期：2015-02-01 00:00:00
abstract：:Contrasting results have been reported about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA). In this study, we pointed to evaluate the incidence of new cases of clinical and subclinical TD in a broad group of patients with PsA versus a control group, matched...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8900-8
更新日期：2017-06-01 00:00:00
abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935511
更新日期：1989-01-01 00:00:00
abstract：:Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:107
更新日期：2002-01-01 00:00:00
abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8823-9
更新日期：2017-02-01 00:00:00
abstract：:Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytoki...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786504
更新日期：1999-01-01 00:00:00
abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:1:65
更新日期：2006-01-01 00:00:00
abstract：:During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8301-y
更新日期：2012-12-01 00:00:00
abstract：:In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4%. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5% of the worldwide population, more frequently in patients with multiple sclerosis, rheu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8418-7
更新日期：2013-07-01 00:00:00
