Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry.

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T cell epitopes to antigen-presenting cells. Mice immunized with CP...

journal_title：Immunologic research

authors： Pouniotis D,Tang CK,Apostolopoulos V,Pietersz G

更新日期：2016-08-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells. These T cells become activated and, in turn, stimu...

journal_title：Immunologic research

authors： Czarneski J,Rassa JC,Ross SR

更新日期：2003-01-01 00:00:00

abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...

journal_title：Immunologic research

authors： Fu C,Jiang A

更新日期：2010-03-01 00:00:00

abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...

journal_title：Immunologic research

authors： Petrovic A,Dorsey M,Miotke J,Shepherd C,Day N

更新日期：2009-01-01 00:00:00

abstract：:Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...

journal_title：Immunologic research

authors： Dusad A,Duryee MJ,Shaw AT,Klassen LW,Anderson DR,Wang D,Ren K,Gravallese EM,O'Dell JR,Mikuls TR,Thiele GM

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...

journal_title：Immunologic research

authors： Lee YH,Song GG

更新日期：2019-10-01 00:00:00

abstract：:The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...

journal_title：Immunologic research

authors： Tang M,Acheampong DO,Wang Y,Xie W,Wang M,Zhang J

更新日期：2016-06-01 00:00:00

abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

journal_title：Immunologic research

authors： Peterson RD

更新日期：2007-01-01 00:00:00

abstract：:Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...

journal_title：Immunologic research

authors： Radosevich M,Ono SJ

更新日期：2003-01-01 00:00:00

abstract：:IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outco...

journal_title：Immunologic research

authors： Pan M,Zhou Q,Zheng S,You X,Li D,Zhang J,Chen C,Xu F,Li Z,Zhou Z,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...

journal_title：Immunologic research

authors： Krangel MS,McMurry MT,Hernandez-Munain C,Zhong XP,Carabana J

更新日期：2000-01-01 00:00:00

abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...

journal_title：Immunologic research

authors： Manzar GS,Kim EM,Rotti P,Zavazava N

更新日期：2014-08-01 00:00:00

abstract：:The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...

journal_title：Immunologic research

authors： Zhou T,Mountz JD,Kimberly RP

更新日期：2002-01-01 00:00:00

abstract：:Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating rece...

journal_title：Immunologic research

authors： Hadad U,Martinez O,Krams SM

更新日期：2014-05-01 00:00:00

abstract：:The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...

journal_title：Immunologic research

authors： Abo T,Kawamura T,Watanabe H

更新日期：2005-01-01 00:00:00

abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...

journal_title：Immunologic research

authors： Cottier F,Pavelka N

更新日期：2012-09-01 00:00:00

abstract：:Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...

journal_title：Immunologic research

authors： Devarajan P,Chen Z

更新日期：2013-12-01 00:00:00

abstract：:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...

journal_title：Immunologic research

authors： Fields ML,Seo SJ,Nish SA,Tsai JH,Caton AJ,Erikson J

更新日期：2003-01-01 00:00:00

abstract：:In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...

journal_title：Immunologic research

authors： Li T,Li WY,Bai HL,Ma HB,Zhang H,Zhu JM,Li XH,Huang HY,Ma YF,Ji XY

更新日期：2011-10-01 00:00:00

abstract：:Eukaryotic cells perceive and respond to microbes, both pathogenic and commensal, by activation of signaling cascades such as the NF-kappaB pathway. Induction of such pathways leads to the upregulation of a program of gene expression that mediates pro-inflammatory and anti-apoptotic effector proteins. This host respon...

journal_title：Immunologic research

authors： Neish AS

更新日期：2004-01-01 00:00:00

abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

journal_title：Immunologic research

authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum ...

journal_title：Immunologic research

authors： Sternberg Z,Sternberg D,Chichelli T,Drake A,Patel N,Kolb C,Chadha K,Yu J,Hojnacki D

更新日期：2016-04-01 00:00:00

abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...

journal_title：Immunologic research

authors： Wasowska BA

更新日期：2010-07-01 00:00:00

abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...

journal_title：Immunologic research

authors： Ramakrishna L,de Vries VC,Curotto de Lafaille MA

更新日期：2012-09-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...

journal_title：Immunologic research

authors： Elhofy A,Kennedy KJ,Fife BT,Karpus WJ

更新日期：2002-01-01 00:00:00

abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...

journal_title：Immunologic research

authors： Xu Y,Huang X,Li F,Liu T,Yang T,Chen F,Zhu J,Pan M,Zhang Y,Wang Y,Fu L,Xiao C,Geng D

更新日期：2020-11-03 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...

journal_title：Immunologic research

authors： Ciccocioppo R,Racca F,Scudeller L,Piralla A,Formagnana P,Pozzi L,Betti E,Vanoli A,Riboni R,Kruzliak P,Baldanti F,Corazza GR

更新日期：2016-02-01 00:00:00