Abstract：
:The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 - 1082 G/A polymorphism showed no association between BD and the - 1082 G allele (odds ratio (OR) = 0.951, 95% confidence interval (CI) = 0.790-1.146, p = 0.601). Meta-analysis of the IL-10 - 819 C/T polymorphism revealed a significant association between BD and the - 819 C allele (OR = 0.751, 95% CI = 0.684-0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the - 819 C allele and BD in Turkish (OR = 0.779, 95% CI = 0.709-0.856, p < 0.001) and Asian (OR = 0.676, 95% CI = 0.631-0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the - 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95% CI = 0.662-0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the - 592 C allele and BD in Asian populations (OR = 0.656, 95% CI = 0.512-0.841, p = 0.001). This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Lee YH,Song GGdoi
10.1007/s12026-019-09102-xsubject
Has Abstractpub_date
2019-10-01 00:00:00pages
424-431issue
4-5eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-019-09102-xjournal_volume
67pub_type
杂志文章,meta分析abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8785-y
更新日期：2016-08-01 00:00:00
abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8264-z
更新日期：2012-06-01 00:00:00
abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8345-z
更新日期：2013-03-01 00:00:00
abstract：:In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4%. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5% of the worldwide population, more frequently in patients with multiple sclerosis, rheu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8418-7
更新日期：2013-07-01 00:00:00
abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8068-3
更新日期：2009-01-01 00:00:00
abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...
journal_title：Immunologic research
pub_type： 传,历史文章,杂志文章,评审
doi：10.1007/s12026-014-8506-3
更新日期：2014-05-01 00:00:00
abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1007/s12026-007-0047-6
更新日期：2007-01-01 00:00:00
abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919132
更新日期：1992-01-01 00:00:00
abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8587-z
更新日期：2015-02-01 00:00:00
abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8115-8
更新日期：2010-03-01 00:00:00
abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...
journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12026-017-8917-z
更新日期：2017-08-01 00:00:00
abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title：Immunologic research
pub_type： 临床试验,杂志文章
doi：10.1007/s12026-017-8967-2
更新日期：2018-02-01 00:00:00
abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:28:3:285
更新日期：2003-01-01 00:00:00
abstract：:Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09133-9
更新日期：2020-06-01 00:00:00
abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:223
更新日期：2002-01-01 00:00:00
abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-019-09112-9
更新日期：2019-12-01 00:00:00
abstract：:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8370-y
更新日期：2013-03-01 00:00:00
abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8982-3
更新日期：2018-02-01 00:00:00
abstract：:The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:22:2-3:253
更新日期：2000-01-01 00:00:00
abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-020-09119-7
更新日期：2020-02-01 00:00:00
abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8737-y
更新日期：2016-02-01 00:00:00
abstract：:The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8806-x
更新日期：2016-08-01 00:00:00
abstract：:Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly by activated liver Kupffer cells and neutrophils. This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8913-3
更新日期：2017-06-01 00:00:00
abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918253
更新日期：1996-01-01 00:00:00
abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:1:65
更新日期：2006-01-01 00:00:00
abstract：:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-017-8931-1
更新日期：2017-08-01 00:00:00
abstract：:Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918217
更新日期：1995-01-01 00:00:00
abstract：:During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8301-y
更新日期：2012-12-01 00:00:00
abstract：:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02918616
更新日期：1992-01-01 00:00:00
