Abstract：
:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before the onset of clinical disease and are associated with severe manifestations of lupus such as glomerulonephritis. Their levels fluctuate with changes in disease activity and, in combination with the levels of complement proteins C3 and C4, are strong indicators of disease flare and treatment response in patients with lupus. The decreased complement levels that are noted during flares of lupus activity are believed to be secondary to increased autoantibody production and immune complex formation that results in tissue damage; however, recent data suggest that complement activation can also drive development of these pathogenic autoantibodies. This review will explore the various roles of complement in the development and pathogenesis of anti-dsDNA antibodies.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Giles BM,Boackle SAdoi
10.1007/s12026-012-8345-zsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
10-21issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
55pub_type
杂志文章,评审abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 历史文章,杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
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更新日期：2002-01-01 00:00:00
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更新日期：2012-09-01 00:00:00
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02918616
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:24:2:111
更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8715-4
更新日期：2016-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2010-07-01 00:00:00
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更新日期：2020-06-01 00:00:00
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更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2015-05-01 00:00:00
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更新日期：2000-01-01 00:00:00
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更新日期：2018-02-01 00:00:00
