Abstract:
:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disruption of these pathways can have dramatic consequences on pathogenesis. Immune responses to infection provide a vital countermeasure by the host but are nonsterilizing. They effect an essential and primary control mechanism for viral growth. Essential nonimmune pathways for effecting control of a viral life cycle relate to the obligate dependency of the virus on its host. For these reasons, we view infections as a highly dynamic interplay that takes place between the pathogen and host. This, in many cases, leads to the establishment of an incurable lifelong infection that remains benign but can become life threatening once key homeostatic pathways are disrupted. We discuss these issues in the context of our studies using cytomegalovirus as a clinically relevant pathogen.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Ghazal P,García-Ramírez J,González-Armas JC,Kurz S,Angulo Adoi
10.1385/IR:21:2-3:219subject
Has Abstractpub_date
2000-01-01 00:00:00pages
219-23issue
2-3eissn
0257-277Xissn
1559-0755pii
IR:21:2-3:219journal_volume
21pub_type
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