Abstract:
:Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Rivas-Santiago B,Castañeda-Delgado JE,de Haro-Acosta J,Torres-Juarez F,Frausto-Lujan I,Marin-Luevano P,González-Amaro R,Enciso-Moreno JAdoi
10.1007/s12026-015-8689-2subject
Has Abstractpub_date
2016-04-01 00:00:00pages
445-54issue
2eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-015-8689-2journal_volume
64pub_type
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