Abstract：
:Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal transduction, and are distinct from other accessory molecules that act independently to regulate B-cell growth. The co-receptor CD19 functions to augment signals by the pre-BCR/BCR and in doing so can modulate B-cell fate decisions at multiple stages of development. In mature B cells, CD19 also associates with complement receptor 2 (CR2/CD21) and is pivotal for transducing signals induced by co-recognition of complement C3d-fixed antigens by the BCR and CD21. In this article, we focus on recent progress in the understanding of CD19 function through the characterization of mouse models that relate in vivo function to biochemical properties of CD19.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Del Nagro CJ,Otero DC,Anzelon AN,Omori SA,Kolla RV,Rickert RCdoi
10.1385/IR:31:2:119subject
Has Abstractpub_date
2005-01-01 00:00:00pages
119-31issue
2eissn
0257-277Xissn
1559-0755pii
IR:31:2:119journal_volume
31pub_type
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