Abstract:
:An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Briones MS,Chow SAdoi
10.1007/s12026-010-8164-zsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
14-26issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
48pub_type
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12026-015-8718-1
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12026-018-9014-7
更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8587-z
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12026-010-8187-5
更新日期:2011-04-01 00:00:00
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8493-4
更新日期:2014-05-01 00:00:00
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