Abstract:
:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow cavity. The PM, in comparison with the conventional aspiration method, can minimize the contamination of bone marrow cells (BMCs) with T cells from the peripheral blood. Therefore, without removing T cells, no graft-versus-host disease (GvHD) develops in the case of the PM. Since BMCs collected by the PM contain not only hemopoietic stem cells (HSCs) but also mesenchymal stem cells (MSCs), the injection of both cells directly into the bone marrow cavity (IBM-BMT) facilitates the engraftment of donor hemopoietic cells. In organ allografts with IBM-BMT, no graft failure occurs even if the radiation dose is reduced. In addition, IBM-BMT is applicable to regeneration therapy and various age-associated diseases such as osteoporosis, since it can efficiently recruit donor-derived normal MSCs. Finally, we show that IBM-BMT in conjunction with donor lymphocyte infusion (DLI) can prevent GvHD but suppress tumor growth. We believe that this strategy heralds a revolution in the field of transplantation (BMT and organ allografts) and regeneration therapy.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Ikehara Sdoi
10.1007/s12026-007-0004-4subject
Has Abstractpub_date
2007-01-01 00:00:00pages
251-60issue
1-3eissn
0257-277Xissn
1559-0755pii
IR:38:1-3:251journal_volume
38pub_type
杂志文章abstract::Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
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pub_type: 临床试验,杂志文章
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更新日期:2018-02-01 00:00:00
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