Abstract：
:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady state, the molecular mechanisms governing their generation, function and regulation remain elusive. Our recent studies have uncovered the E-cadherin/beta-catenin-signaling pathway as a novel maturation pathway that achieves DC maturation without inflammatory cytokines. As a result, E-cadherin-stimulated DCs elicited an entirely different T cell response in vivo, generating T cells with a regulatory as opposed to an effector phenotype. These DCs induced tolerance in vivo and more importantly, immunization with these DCs provided complete protection against autoimmune diseases in experimental autoimmune encephalomyelitis (EAE). Interestingly, while DCs matured upon disruption of E-cadherin-mediated clusters were functional tolerogenic, upon further TLR ligation, they displayed a strong Th1 cytokine profile and much enhanced antigen presentation capacity consistent with enhanced immunity. Thus, E-cadherin/beta-catenin-signaling might serve as a novel signal that contributes to the elusive steady-state "tolerogenic DCs". Targeting E-cadherin/beta-catenin signaling to either enhance or reduce DC-mediated tolerance might represent an attractive new strategy to achieve antigen-specific immunotherapy for cancers and autoimmune/inflammatory diseases.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Fu C,Jiang Adoi
10.1007/s12026-009-8126-5subject
Has Abstractpub_date
2010-03-01 00:00:00pages
72-8issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
46pub_type
杂志文章,评审abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8996-5
更新日期：2018-06-01 00:00:00
abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8264-z
更新日期：2012-06-01 00:00:00
abstract：:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:293
更新日期：2000-01-01 00:00:00
abstract：:Limited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccin...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-019-09107-6
更新日期：2019-10-01 00:00:00
abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8102-0
更新日期：2009-12-01 00:00:00
abstract：:Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8215-0
更新日期：2011-08-01 00:00:00
abstract：:The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8576-2
更新日期：2014-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:1:23
更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-010-8164-z
更新日期：2010-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919739
更新日期：1991-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8423-x
更新日期：2013-07-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8673-x
更新日期：2016-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8621-1
更新日期：2015-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09133-9
更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:469
更新日期：2003-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9046-z
更新日期：2019-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8115-8
更新日期：2010-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8296-4
更新日期：2012-09-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9014-7
更新日期：2018-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12026-017-8917-z
更新日期：2017-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:223
更新日期：2002-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-010-8175-9
更新日期：2011-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8024-2
更新日期：2009-01-01 00:00:00
abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8084-3
更新日期：2009-01-01 00:00:00
