Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report.

abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...

journal_title：Immunologic research

authors： Murakawa Y,Strober W,James SP

更新日期：1991-01-01 00:00:00

abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...

journal_title：Immunologic research

authors： Cronin DC 2nd,Lancki DW,Fitch FW

更新日期：1994-01-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...

journal_title：Immunologic research

authors： Can M,Uygur F,Tanrıverdi H,Acıkgoz B,Alper B,Guven B

更新日期：2016-12-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...

journal_title：Immunologic research

authors： Elhofy A,Kennedy KJ,Fife BT,Karpus WJ

更新日期：2002-01-01 00:00:00

abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...

journal_title：Immunologic research

authors： Brooks WH

更新日期：2018-12-01 00:00:00

abstract：:Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...

journal_title：Immunologic research

authors： Radosevich M,Ono SJ

更新日期：2003-01-01 00:00:00

abstract：:Gender has long been known to be a contributory factor in the incidence and progression of disorders associated with immune system dysregulation. More recently, evidence has accumulated that gender may also play an important role in infectious disease susceptibility. In general, females generate more robust and potent...

journal_title：Immunologic research

authors： Marriott I,Huet-Hudson YM

更新日期：2006-01-01 00:00:00

abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

journal_title：Immunologic research

authors： Carrero JA,Unanue ER

更新日期：2007-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

journal_title：Immunologic research

authors： Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

更新日期：2017-08-01 00:00:00

abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...

journal_title：Immunologic research

authors： Yin W,Wei X,Jiang J,Fan K,Zhao J,Sun N,Wang Z,Sun Y,Ma H,Zhao X,Li H

更新日期：2016-08-01 00:00:00

abstract：:Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...

journal_title：Immunologic research

authors： Snyder CM

更新日期：2011-12-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...

journal_title：Immunologic research

authors： Shi D,Li D,Yin Q,Qiu Y,Yan H,Shen Y,Lu G,Liu W

更新日期：2015-03-01 00:00:00

abstract：:Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...

journal_title：Immunologic research

authors： Krakauer T

更新日期：1999-01-01 00:00:00

abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...

journal_title：Immunologic research

authors： Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich W

更新日期：2009-01-01 00:00:00

abstract：:Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal t...

journal_title：Immunologic research

authors： Del Nagro CJ,Otero DC,Anzelon AN,Omori SA,Kolla RV,Rickert RC

更新日期：2005-01-01 00:00:00

abstract：:The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...

journal_title：Immunologic research

authors： Finn OJ,Salter RD

更新日期：2006-01-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...

journal_title：Immunologic research

authors： Toapanta FR,Ross TM

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...

journal_title：Immunologic research

authors： Shrivastava G,León-Juárez M,García-Cordero J,Meza-Sánchez DE,Cedillo-Barrón L

更新日期：2016-12-01 00:00:00

abstract：:CD27 is a tumor necrosis factor (TNF) receptor family member whose expression is limited to cells of the lymphoid lineage. Constitutively expressed on T lymphocytes, it is a costimulatory molecule for a regulatory subset. Induced on B lymphocytes after antigenic challenge, it is a marker of memory cells. CD70, CD27 li...

journal_title：Immunologic research

authors： Jacquot S

更新日期：2000-01-01 00:00:00

abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...

journal_title：Immunologic research

authors： Fu C,Jiang A

更新日期：2010-03-01 00:00:00

abstract：:The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...

journal_title：Immunologic research

authors： Tang M,Acheampong DO,Wang Y,Xie W,Wang M,Zhang J

更新日期：2016-06-01 00:00:00

abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

journal_title：Immunologic research

authors： Peterson RD

更新日期：2007-01-01 00:00:00

abstract：:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...

journal_title：Immunologic research

authors： Fields ML,Seo SJ,Nish SA,Tsai JH,Caton AJ,Erikson J

更新日期：2003-01-01 00:00:00

abstract：:CD6 is a cell surface receptor expressed on the majority of T cells and a subset of B cells. When expressed, CD6 contributes to lymphocyte activation through its extracellular domain 1, while adhesion and cellular migration are related to the extracellular scavenger receptor cysteine-rich domain (SRCR-D)-3 of CD6. Ito...

journal_title：Immunologic research

authors： Le Dantec C,Alonso R,Fali T,Montero E,Devauchelle V,Saraux A,Pers JO,Renaudineau Y

更新日期：2013-07-01 00:00:00

abstract：:CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...

journal_title：Immunologic research

authors： Díaz-Montero CM,Zidan AA,Pallin MF,Anagnostopoulos V,Salem ML,Wieder E,Komanduri K,Montero AJ,Lichtenheld MG

更新日期：2013-12-01 00:00:00

abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...

journal_title：Immunologic research

authors： Livingstone AM,Wilson EB,Ontiveros F,Wang JC

更新日期：2009-12-01 00:00:00

abstract：:During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...

journal_title：Immunologic research

authors： Alexandropoulos K,Danzl NM

更新日期：2012-12-01 00:00:00