Abstract：
:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the cell cycle, and the level of cytolytic activity is independent of cellular proliferation. The requirement for proliferation by primary responding populations may reflect the need for clonal expansion of a few inherently cytolytic effector cells in order to reach a threshold number which can readily be detected in conventional cytolytic assays. Alternatively, proliferation may be required for cytolytic T lymphocyte precursors to differentiate into mature, functional cytolytic cells. Using CD8+ T cells which express an antigen-specific transgenic alpha/beta T cell receptor, we have studied the requirements for acquisition of cytolytic capacity. Stimulation of the T cell receptor alone appears to be sufficient to render naive, CD8+ transgenic T cells sensitive to the growth effects of interleukin-2 (IL-2), and in some circumstances to interleukin-4 (IL-4), but not to induce either lymphokine production or cytolytic activity. Costimulatory molecules expressed by allogenic stimulating cells appear to be required for lymphokine production, and CD8+ transgenic T cells initially appear to secrete only IL-2 and interferon-gamma. Stimulation of the T cell receptor of naive, CD8+ transgenic T cells appears to induce cytolytic activity only if cell proliferation occurs, either in response to IL-2 produced by the stimulated cells themselves when costimulatory molecules are present, or to IL-2 or IL-4 from exogenous sources if costimulatory molecules are absent.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Cronin DC 2nd,Lancki DW,Fitch FWdoi
10.1007/BF02935614subject
Has Abstractpub_date
1994-01-01 00:00:00pages
215-33issue
4eissn
0257-277Xissn
1559-0755journal_volume
13pub_type
杂志文章abstract：:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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更新日期：2005-01-01 00:00:00
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更新日期：2010-03-01 00:00:00
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更新日期：2000-01-01 00:00:00
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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更新日期：2018-12-01 00:00:00
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更新日期：2011-08-01 00:00:00
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更新日期：2014-08-01 00:00:00
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更新日期：2007-01-01 00:00:00
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更新日期：2016-06-01 00:00:00
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更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 临床试验,杂志文章
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更新日期：2018-02-01 00:00:00
