Abstract：
:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and elicits anti-HCV T cell responses. Ten patients with HCV (genotype 1) were vaccinated with monocyte-derived DCs, generated in the presence of IFN-α (IFN-DCs) and pulsed with recombinant HCV Core and NS3 proteins. Treatment schedule included four subcutaneous vaccinations with 1 week interval and six vaccinations with month interval. No serious adverse events or an increase in hepatitis C biochemical activity were registered after vaccination. Using ex vivo assays for the detection of proliferative responses, IFN-γ production and CD8+ degranulation have shown that immunotherapy elicited antigen-specific responses in all patients although individual heterogeneity existed within their types, magnitude, and timing. Core/NS3-specific proliferative response and CD8+ T cell degranulation have already been registered after the first course of vaccination. Of note, Core-specific responses had higher magnitude. The appearance of antigen-specific IFN-γ responses was registered after the second vaccination course. Vaccination did not cause Th2 response and expansion of the CD4+CD25+CD127- regulatory T cells. Generated immune responses failed to provide virus elimination. Nevertheless, there were inverse correlations between viral load and NS3-specific proliferation (R S = 0.62; p = 0.05) and IFN-γ secretion (R S = - 0.82; p = 0.001) at 6-month post-treatment period. Immunotherapy with IFN-DCs was safe and elicited HCV-specific T cell responses which were insufficient to eliminate viruses but could be implicated in the restriction of viral replication.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Chernykh E,Leplina O,Oleynik E,Tikhonova M,Tyrinova T,Starostina N,Ostanin Adoi
10.1007/s12026-017-8967-2subject
Has Abstractpub_date
2018-02-01 00:00:00pages
31-43issue
1eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-017-8967-2journal_volume
66pub_type
临床试验,杂志文章abstract：:Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9046-z
更新日期：2019-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-010-8164-z
更新日期：2010-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:31:3:177
更新日期：2005-01-01 00:00:00
abstract：:The initial stages of an immune response are regulated at the level of the cell-surface antigen and Fc receptors. The extracellular portions of these receptors provide immune specificity and determine the nature of the responding effector cells, whereas the intracellular portion transduces signals into the cell and de...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786325
更新日期：1997-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8823-9
更新日期：2017-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09115-x
更新日期：2020-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786504
更新日期：1999-01-01 00:00:00
abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8390-2
更新日期：2013-05-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8876-9
更新日期：2016-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8769-3
更新日期：2016-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:22:2-3:253
更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8215-0
更新日期：2011-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-012-8347-x
更新日期：2013-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8869-8
更新日期：2016-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,meta分析
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更新日期：2019-10-01 00:00:00
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更新日期：2015-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
