Abstract：
:Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased production of cAMP, and activation of PKA. PKA I, but not PKA II, participates in the inhibitory effects of adenosine. Blocking regulatory, but not catalytic, subunits of PKA I abrogates the inhibitory effects of adenosine. These findings suggest that tumor-produced adenosine inhibits the activity of NK and other effector cells and thereby protects tumors from immune-mediated destruction.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Raskovalova T,Lokshin A,Huang X,Jackson EK,Gorelik Edoi
10.1385/IR:36:1:91subject
Has Abstractpub_date
2006-01-01 00:00:00pages
91-9issue
1-3eissn
0257-277Xissn
1559-0755pii
IR:36:1:91journal_volume
36pub_type
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