Abstract:
:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being used in virtually all patients with B-cell lymphomas either alone or in combination with chemotherapy. Despite its excellent safety and efficacy profile, only a small portion of B-cell lymphoma patients treated with rituximab as a single agent have sustained complete remissions. Combining rituximab with standard chemotherapy regimens is associated with higher response rates, and improved survival in a subset of patients. Unfortunately, a significant percentage of patients who initially respond to rituximab eventually relapse, and there are patients that demonstrate intrinsic resistance to initial therapy. In the last decade, ongoing scientific research has led to a better understanding of rituximab-associated cytotoxic mechanisms against lymphoma target cells. Scientific efforts are increasingly being focused in developing new strategies to improve mAb activity. Various strategies include the following: combining rituximab with different biologic agents (e.g. cytokines, immunomodulatory drugs); developing novel antibody constructs (including bi-specific antibodies); and/or inhibiting signaling pathways associated with lymphomagenesis and immuno-chemotherapy resistance. In this review article, we will provide an overview of various rituximab-associated cytotoxic mechanisms and novel strategies to improve mAb activity against B-cell lymphoma.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MSdoi
10.1007/s12026-009-8121-xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
192-205issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
46pub_type
杂志文章,评审abstract::Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...
journal_title:Immunologic research
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doi:10.1007/s12026-014-8546-8
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journal_title:Immunologic research
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doi:10.1007/s12026-007-0058-3
更新日期:2008-01-01 00:00:00
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abstract::The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...
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更新日期:2012-06-01 00:00:00
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doi:10.1007/s12026-014-8562-8
更新日期:2015-03-01 00:00:00
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract::CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8456-1
更新日期:2013-12-01 00:00:00
abstract::The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...
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pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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更新日期:2018-12-01 00:00:00
abstract::The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8769-3
更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8448-1
更新日期:2013-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8457-0
更新日期:2013-12-01 00:00:00
abstract::The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
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pub_type: 临床试验,杂志文章
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更新日期:2018-02-01 00:00:00
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更新日期:2009-01-01 00:00:00
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