Abstract：
:Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in association with rising antidonor antibody titers and allograft vasculopathy, despite continuing anti-CD40L therapy. In contrast, the primary humoral response to T helper dependent influenza viral antigen is inhibited during anti-CD40L therapy, and responses to subsequent immunization are blunted after discontinuation of therapy. These results are encouraging with regard to the tolerogenic potential of costimulatory blockade for specific T helper dependent antigens. However, these findings also indicate that pathogenic allograft responses in primates are probably not entirely CD40L-dependent. As such, additional immunomodulatory strategies are needed to facilitate tolerance to a transplanted organ.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Pierson RN 3rd,Crowe JE Jr,Pfeiffer S,Atkinson J,Azimzadeh A,Miller GGdoi
10.1385/IR:23:2-3:253subject
Has Abstractpub_date
2001-01-01 00:00:00pages
253-62issue
2-3eissn
0257-277Xissn
1559-0755pii
IR:23:2-3:253journal_volume
23pub_type
杂志文章abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2006-01-01 00:00:00
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更新日期：1992-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2013-03-01 00:00:00
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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更新日期：1996-01-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2019-02-01 00:00:00
