Presentation of cytosolic antigens via MHC class II molecules.

abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...

journal_title：Immunologic research

authors： Brooks WH

更新日期：2018-12-01 00:00:00

abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...

journal_title：Immunologic research

authors： Townsend MH,Bennion K,Robison RA,O'Neill KL

更新日期：2020-02-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...

journal_title：Immunologic research

authors： Can M,Uygur F,Tanrıverdi H,Acıkgoz B,Alper B,Guven B

更新日期：2016-12-01 00:00:00

abstract：:Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...

journal_title：Immunologic research

authors： Rüthlein J,Heinze G

更新日期：1991-01-01 00:00:00

abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...

journal_title：Immunologic research

authors： Aldo-Benson M,Borel H,Scheiderer-Pratt L,Borel Y

更新日期：1989-01-01 00:00:00

abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...

journal_title：Immunologic research

authors： Pallikkuth S,Pahwa S

更新日期：2013-12-01 00:00:00

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...

journal_title：Immunologic research

authors： Zhou T,Mountz JD,Kimberly RP

更新日期：2002-01-01 00:00:00

abstract：:Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...

journal_title：Immunologic research

authors： Rojas CM,Borella E,Palma L,Ragozzino S,De Ramón E,Gomez-Huelgas R,Punzi L,Doria A

更新日期：2015-02-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...

journal_title：Immunologic research

authors： Hogan WJ,Storb R

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...

journal_title：Immunologic research

authors： Raskovalova T,Lokshin A,Huang X,Jackson EK,Gorelik E

更新日期：2006-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

journal_title：Immunologic research

authors： Carrero JA,Unanue ER

更新日期：2007-01-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...

journal_title：Immunologic research

authors： Zhang Y,Zhou B

更新日期：2012-06-01 00:00:00

abstract：:Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...

journal_title：Immunologic research

authors： Krakauer T

更新日期：1999-01-01 00:00:00

abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...

journal_title：Immunologic research

authors： Xu Y,Huang X,Li F,Liu T,Yang T,Chen F,Zhu J,Pan M,Zhang Y,Wang Y,Fu L,Xiao C,Geng D

更新日期：2020-11-03 00:00:00

abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...

journal_title：Immunologic research

authors： Heber-Katz E

更新日期：1998-01-01 00:00:00

abstract：:Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regu...

journal_title：Immunologic research

authors： Pavlov VA,Tracey KJ

更新日期：2015-12-01 00:00:00

abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...

journal_title：Immunologic research

authors： Masilamani M,Wei J,Sampson HA

更新日期：2012-12-01 00:00:00

abstract：:IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outco...

journal_title：Immunologic research

authors： Pan M,Zhou Q,Zheng S,You X,Li D,Zhang J,Chen C,Xu F,Li Z,Zhou Z,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can affect immune responses by inducing immune regulation. We recently reported that a single course of treatment with a non-FcR binding anti-CD3 MAb, hOKT3gamm...

journal_title：Immunologic research

authors： Herold KC,Taylor L

更新日期：2003-01-01 00:00:00

abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...

journal_title：Immunologic research

authors： Ramesh N,Geha R

更新日期：2009-01-01 00:00:00

abstract：:Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating rece...

journal_title：Immunologic research

authors： Hadad U,Martinez O,Krams SM

更新日期：2014-05-01 00:00:00

abstract：:The generation and maintenance of B lymphocytes is controlled by biochemical signals transmitted by the B cell antigen receptor(BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs acti...

journal_title：Immunologic research

authors： Khan WN

更新日期：2001-01-01 00:00:00

abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

journal_title：Immunologic research

authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

更新日期：2002-01-01 00:00:00

abstract：:In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...

journal_title：Immunologic research

authors： Li T,Li WY,Bai HL,Ma HB,Zhang H,Zhu JM,Li XH,Huang HY,Ma YF,Ji XY

更新日期：2011-10-01 00:00:00

abstract：:Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...

journal_title：Immunologic research

authors： Vonderheide RH,June CH

更新日期：2003-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

journal_title：Immunologic research

authors： Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

更新日期：2017-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...

journal_title：Immunologic research

authors： Himeno K,Hisaeda H

更新日期：1996-01-01 00:00:00