Abstract：
:Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without significant medical co-morbidities. Given the age profiles of patients with candidate hematological malignancies, a majority of patients are therefore ineligible for myeloablative therapy. Over the past few years the ability to achieve hematopoietic stem cell engraftment using immunosuppressive but non-myeloablative conditioning regimens has made it possible to consider a much broader group of patients for allogeneic HSCT. The discovery that the hematopoietic graft itself can contribute to the eradication of malignant cells through a graft-versus-malignancy (GVM) effect, independent of the conditioning regimen, has led to investigation of reduced intensity conditioning regimens for a variety of malignant diseases. Over the past few years there has been a dramatic increase in the number of patients undergoing reduced intensity conditioning for both malignant and nonmalignant conditions. This review will focus only on the use of such therapy for malignant disease.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Hogan WJ,Storb Rdoi
10.1385/IR:28:1:1subject
Has Abstractpub_date
2003-01-01 00:00:00pages
1-11issue
1eissn
0257-277Xissn
1559-0755pii
IR:28:1:1journal_volume
28pub_type
杂志文章,评审abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-011-8225-y
更新日期：2011-08-01 00:00:00
abstract：:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8528-x
更新日期：2014-08-01 00:00:00
abstract：:Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:30:1:035
更新日期：2004-01-01 00:00:00
abstract：:Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8479-7
更新日期：2014-01-01 00:00:00
abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:219
更新日期：2000-01-01 00:00:00
abstract：:Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:33:3:223
更新日期：2005-01-01 00:00:00
abstract：:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8370-y
更新日期：2013-03-01 00:00:00
abstract：:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-017-8931-1
更新日期：2017-08-01 00:00:00
abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title：Immunologic research
pub_type： 临床试验,杂志文章
doi：10.1007/s12026-017-8967-2
更新日期：2018-02-01 00:00:00
abstract：:Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9030-7
更新日期：2018-12-01 00:00:00
abstract：:Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0070-7
更新日期：2007-01-01 00:00:00
abstract：:Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9035-2
更新日期：2019-02-01 00:00:00
abstract：:Various multisubunit receptors of the immune system share similarities in structure and induce closely related signal transduction pathways upon ligand binding. Examples include the T cell antigen receptor (TCR), the B cell antigen receptor (BCR), and the high-affinity receptor for immunoglobulin E (Fc epsilon RI). Al...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918171
更新日期：1995-01-01 00:00:00
abstract：:Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章,评审
doi：10.1385/IR:32:1-3:193
更新日期：2005-01-01 00:00:00
abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0017-z
更新日期：2007-01-01 00:00:00
abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8960-9
更新日期：2018-02-01 00:00:00
abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-019-09112-9
更新日期：2019-12-01 00:00:00
abstract：:In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe h...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-019-9066-3
更新日期：2019-02-01 00:00:00
abstract：:Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786484
更新日期：1999-01-01 00:00:00
abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786399
更新日期：1997-01-01 00:00:00
abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8647-z
更新日期：2015-06-01 00:00:00
abstract：:CD6 is a cell surface receptor expressed on the majority of T cells and a subset of B cells. When expressed, CD6 contributes to lymphocyte activation through its extracellular domain 1, while adhesion and cellular migration are related to the extracellular scavenger receptor cysteine-rich domain (SRCR-D)-3 of CD6. Ito...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8423-x
更新日期：2013-07-01 00:00:00
abstract：:Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:341
更新日期：2003-01-01 00:00:00
abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:32:1-3:293
更新日期：2005-01-01 00:00:00
abstract：:Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8542-z
更新日期：2014-08-01 00:00:00
abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8792-z
更新日期：2016-08-01 00:00:00
abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-010-8193-7
更新日期：2011-04-01 00:00:00
