Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes.

abstract：:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...

journal_title：Immunologic research

authors： Rosean TR,Tompkins VS,Tricot G,Holman CJ,Olivier AK,Zhan F,Janz S

更新日期：2014-08-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...

journal_title：Immunologic research

authors： Giraldo DM,Hernandez JC,Urcuqui-Inchima S

更新日期：2016-12-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...

journal_title：Immunologic research

authors： Hogan WJ,Storb R

更新日期：2003-01-01 00:00:00

abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...

journal_title：Immunologic research

authors： O'Rourke DM,Greene MI

更新日期：1998-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...

journal_title：Immunologic research

authors： Berges C,Chatterjee M,Topp MS,Einsele H

更新日期：2016-06-01 00:00:00

abstract：:Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...

journal_title：Immunologic research

authors： Fattahi F,Grailer JJ,Jajou L,Zetoune FS,Andjelkovic AV,Ward PA

更新日期：2015-03-01 00:00:00

abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...

journal_title：Immunologic research

authors： Bizjak M,Bruck O,Praprotnik S,Dahan S,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...

journal_title：Immunologic research

authors： Tang M,Acheampong DO,Wang Y,Xie W,Wang M,Zhang J

更新日期：2016-06-01 00:00:00

abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...

journal_title：Immunologic research

authors： Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich W

更新日期：2009-01-01 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...

journal_title：Immunologic research

authors： Reeves E,Elliott T,James E,Edwards CJ

更新日期：2014-12-01 00:00:00

abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...

journal_title：Immunologic research

authors： Lu Y,Durkin JP

更新日期：1997-01-01 00:00:00

abstract：:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...

journal_title：Immunologic research

authors： Hauck CR,Klingbeil CK,Schlaepfer DD

更新日期：2000-01-01 00:00:00

abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...

journal_title：Immunologic research

authors： Petrovic A,Dorsey M,Miotke J,Shepherd C,Day N

更新日期：2009-01-01 00:00:00

abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...

journal_title：Immunologic research

authors： Ramakrishna L,de Vries VC,Curotto de Lafaille MA

更新日期：2012-09-01 00:00:00

abstract：:Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly by activated liver Kupffer cells and neutrophils. This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses...

journal_title：Immunologic research

authors： Jiang L,Ke M,Yue S,Xiao W,Yan Y,Deng X,Ying QL,Li J,Ke B

更新日期：2017-06-01 00:00:00

abstract：:The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...

journal_title：Immunologic research

authors： Krangel MS,McMurry MT,Hernandez-Munain C,Zhong XP,Carabana J

更新日期：2000-01-01 00:00:00

abstract：:CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...

journal_title：Immunologic research

authors： Díaz-Montero CM,Zidan AA,Pallin MF,Anagnostopoulos V,Salem ML,Wieder E,Komanduri K,Montero AJ,Lichtenheld MG

更新日期：2013-12-01 00:00:00

abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...

journal_title：Immunologic research

authors： Shu C,Sun L,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...

journal_title：Immunologic research

authors： Ghazal P,García-Ramírez J,González-Armas JC,Kurz S,Angulo A

更新日期：2000-01-01 00:00:00

abstract：:Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...

journal_title：Immunologic research

authors： Sekar Y,Moon TC,Muñoz S,Befus AD

更新日期：2005-01-01 00:00:00

abstract：:The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...

journal_title：Immunologic research

authors： Robertson SJ,Mitzel DN,Taylor RT,Best SM,Bloom ME

更新日期：2009-01-01 00:00:00

abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

journal_title：Immunologic research

authors： Peterson RD

更新日期：2007-01-01 00:00:00

abstract：:The MHC class II antigen processing pathway provides a mechanism to selectively present peptides generated in the endosomal compartments of antigen presenting cells to CD4+ T cells. Transport of newly synthesized class II molecules to the endosomal pathway requires the function of an accessory protein, invariant chain...

journal_title：Immunologic research

authors： Jensen PE,Weber DA,Thayer WP,Chen X,Dao CT

更新日期：1999-01-01 00:00:00

abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

journal_title：Immunologic research

authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

更新日期：2002-01-01 00:00:00

abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...

journal_title：Immunologic research

authors： Abdulhaqq SA,Weiner DB

更新日期：2008-01-01 00:00:00

abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

journal_title：Immunologic research

authors： Krstic A,Mojsilovic S,Jovcic G,Bugarski D

更新日期：2012-04-01 00:00:00

abstract：:Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...

journal_title：Immunologic research

authors： Yan HX,Li WW,Zhang Y,Wei XW,Fu LX,Shen GB,Yin T,Li XY,Shi HS,Wan Y,Zhang QY,Li J,Yang SY,Wei YQ

更新日期：2014-10-01 00:00:00

abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...

journal_title：Immunologic research

authors： Scavuzzi BM,Simão ANC,Iriyoda TMV,Lozovoy MAB,Stadtlober NP,Franchi Santos LFDR,Flauzino T,de Medeiros FA,de Sá MC,Consentin L,Reiche EMV,Maes M,Dichi I

更新日期：2018-02-01 00:00:00

abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...

journal_title：Immunologic research

authors： Ciccocioppo R,Racca F,Scudeller L,Piralla A,Formagnana P,Pozzi L,Betti E,Vanoli A,Riboni R,Kruzliak P,Baldanti F,Corazza GR

更新日期：2016-02-01 00:00:00

abstract：:Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone ...

journal_title：Immunologic research

authors： da Silva Sacerdote AB,Filgueira NA,de Barros Barreto S,Batista AD,Lopes EP

更新日期：2020-06-01 00:00:00