Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus.

abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...

journal_title：Immunologic research

authors： Xu Y,Huang X,Li F,Liu T,Yang T,Chen F,Zhu J,Pan M,Zhang Y,Wang Y,Fu L,Xiao C,Geng D

更新日期：2020-11-03 00:00:00

abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...

journal_title：Immunologic research

authors： Pallikkuth S,Pahwa S

更新日期：2013-12-01 00:00:00

abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...

journal_title：Immunologic research

authors： Wasowska BA

更新日期：2010-07-01 00:00:00

abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...

journal_title：Immunologic research

authors： Giles BM,Boackle SA

更新日期：2013-03-01 00:00:00

abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...

journal_title：Immunologic research

authors： Parker KC,Shields M,DiBrino M,Brooks A,Coligan JE

更新日期：1995-01-01 00:00:00

abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...

journal_title：Immunologic research

authors： Chernykh E,Leplina O,Oleynik E,Tikhonova M,Tyrinova T,Starostina N,Ostanin A

更新日期：2018-02-01 00:00:00

abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...

journal_title：Immunologic research

authors： Jongstra-Bilen J,Jongstra J

更新日期：2006-01-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...

journal_title：Immunologic research

authors： Lambert J,Mejia S,Vojdani A

更新日期：2019-02-01 00:00:00

abstract：:Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can affect immune responses by inducing immune regulation. We recently reported that a single course of treatment with a non-FcR binding anti-CD3 MAb, hOKT3gamm...

journal_title：Immunologic research

authors： Herold KC,Taylor L

更新日期：2003-01-01 00:00:00

abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...

journal_title：Immunologic research

authors： Ramakrishna L,de Vries VC,Curotto de Lafaille MA

更新日期：2012-09-01 00:00:00

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...

journal_title：Immunologic research

authors： Ziegler HK

更新日期：2004-01-01 00:00:00

abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...

journal_title：Immunologic research

authors： Santos P,Arumemi F,Park KS,Borghesi L,Milcarek C

更新日期：2011-08-01 00:00:00

abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...

journal_title：Immunologic research

authors： Qian L,Flood PM

更新日期：2008-01-01 00:00:00

abstract：:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...

journal_title：Immunologic research

authors： Dubey C,Croft M

更新日期：1996-01-01 00:00:00

abstract：:This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum ...

journal_title：Immunologic research

authors： Sternberg Z,Sternberg D,Chichelli T,Drake A,Patel N,Kolb C,Chadha K,Yu J,Hojnacki D

更新日期：2016-04-01 00:00:00

abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...

journal_title：Immunologic research

authors： O'Rourke DM,Greene MI

更新日期：1998-01-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...

journal_title：Immunologic research

authors： Snook AE,Magee MS,Waldman SA

更新日期：2011-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pa...

journal_title：Immunologic research

authors： Wang J,Peng H,Tian J,Ma J,Tang X,Rui K,Tian X,Wang Y,Chen J,Lu L,Xu H,Wang S

更新日期：2016-04-01 00:00:00

abstract：:We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...

journal_title：Immunologic research

authors： Bogdanos DP,Smyk DS,Invernizzi P,Rigopoulou EI,Blank M,Sakkas L,Pouria S,Shoenfeld Y

更新日期：2013-07-01 00:00:00

abstract：:Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...

journal_title：Immunologic research

authors： Fattahi F,Grailer JJ,Jajou L,Zetoune FS,Andjelkovic AV,Ward PA

更新日期：2015-03-01 00:00:00

abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...

journal_title：Immunologic research

authors： Scavuzzi BM,Simão ANC,Iriyoda TMV,Lozovoy MAB,Stadtlober NP,Franchi Santos LFDR,Flauzino T,de Medeiros FA,de Sá MC,Consentin L,Reiche EMV,Maes M,Dichi I

更新日期：2018-02-01 00:00:00

abstract：:The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...

journal_title：Immunologic research

authors： Esposito S,Prada E,Mastrolia MV,Tarantino G,Codecà C,Rigante D

更新日期：2014-12-01 00:00:00

abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...

journal_title：Immunologic research

authors： Manzar GS,Kim EM,Rotti P,Zavazava N

更新日期：2014-08-01 00:00:00

abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

journal_title：Immunologic research

authors： Carrero JA,Unanue ER

更新日期：2007-01-01 00:00:00

abstract：:T follicular regulatory (Tfr) cell is a CXCR5+Foxp3+ subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses and modulating the immune environment in the lymph nodes. Studies have shown that the proportion of Tfr cells may increase during acute inflammation. In this study, we inv...

journal_title：Immunologic research

authors： Li H,Zhou R,Wang C,Li Y,Zheng G,Jiang S,Dong T,Bai J,Xu S

更新日期：2018-08-01 00:00:00

abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

journal_title：Immunologic research

authors： Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

更新日期：2016-08-01 00:00:00