Abstract：
:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes containing particular peptides by applying coefficients, deduced from a large amount of binding data, that quantify the relative contribution of each amino acid at each position. In this review, we describe the molecular basis for these coefficients and demonstrate that estimates of binding stability based on the coefficients are generally concordant with experimental measurements of binding affinities. Peptides that contained cysteine were predicted less well, possibly because of complications resulting from peptide dimerization and oxidation. Apparently, peptide binding affinity is largely controlled by the rate of dissociation of the HLA/peptide/beta 2-microglobulin complex, whereas the rate of formation of the complex has less impact on peptide affinity. Although peptides that bind tightly to HLA-A2, including many antigenic peptides bind much more weakly. Therefore, a full understanding of why certain peptides are immunodominant will require further research.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Parker KC,Shields M,DiBrino M,Brooks A,Coligan JEdoi
10.1007/BF02918496subject
Has Abstractpub_date
1995-01-01 00:00:00pages
34-57issue
1eissn
0257-277Xissn
1559-0755journal_volume
14pub_type
杂志文章,评审abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786443
更新日期：1998-01-01 00:00:00
abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8115-8
更新日期：2010-03-01 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:28:1:1
更新日期：2003-01-01 00:00:00
abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8121-x
更新日期：2010-03-01 00:00:00
abstract：:Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:23:2-3:253
更新日期：2001-01-01 00:00:00
abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:219
更新日期：2000-01-01 00:00:00
abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
abstract：:The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:21:2-3:129
更新日期：2000-01-01 00:00:00
abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8331-5
更新日期：2012-12-01 00:00:00
abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8206-1
更新日期：2011-08-01 00:00:00
abstract：:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-017-8931-1
更新日期：2017-08-01 00:00:00
abstract：:Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8411-1
更新日期：2013-07-01 00:00:00
abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-017-8926-y
更新日期：2017-08-01 00:00:00
abstract：:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:293
更新日期：2000-01-01 00:00:00
abstract：:The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8065-6
更新日期：2009-01-01 00:00:00
abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8823-9
更新日期：2017-02-01 00:00:00
abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8126-5
更新日期：2010-03-01 00:00:00
abstract：:It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8017-1
更新日期：2008-01-01 00:00:00
abstract：:Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plas...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8943-x
更新日期：2017-10-01 00:00:00
abstract：:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0004-4
更新日期：2007-01-01 00:00:00
abstract：:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918501
更新日期：1996-01-01 00:00:00
abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8920-4
更新日期：2017-08-01 00:00:00
abstract：:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:219
更新日期：2003-01-01 00:00:00
abstract：:Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:341
更新日期：2003-01-01 00:00:00
abstract：:Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786484
更新日期：1999-01-01 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:32:1-3:075
更新日期：2005-01-01 00:00:00
abstract：:IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outco...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8995-6
更新日期：2018-06-01 00:00:00
