Abstract:
:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (PTKs), highlight some of the signals that activate these PTKs, and detail the molecules that functionally interact and signal transduction pathways that may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Hauck CR,Klingbeil CK,Schlaepfer DDdoi
10.1385/IR:21:2-3:293subject
Has Abstractpub_date
2000-01-01 00:00:00pages
293-303issue
2-3eissn
0257-277Xissn
1559-0755pii
IR:21:2-3:293journal_volume
21pub_type
杂志文章,评审abstract::Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02918616
更新日期:1992-01-01 00:00:00
abstract::This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8673-x
更新日期:2016-04-01 00:00:00
abstract::Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8562-8
更新日期:2015-03-01 00:00:00
abstract::Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors-chemotaxis for chasing down infectious pathogens and phagocyto...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8056-7
更新日期:2009-01-01 00:00:00
abstract::Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8024-2
更新日期:2009-01-01 00:00:00
abstract::Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly by activated liver Kupffer cells and neutrophils. This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-017-8913-3
更新日期:2017-06-01 00:00:00
abstract::Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0017-z
更新日期:2007-01-01 00:00:00
abstract::The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09115-x
更新日期:2020-02-01 00:00:00
abstract::Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:219
更新日期:2003-01-01 00:00:00
abstract::The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8065-6
更新日期:2009-01-01 00:00:00
abstract::We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0004-4
更新日期:2007-01-01 00:00:00
abstract::Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-009-8121-x
更新日期:2010-03-01 00:00:00
abstract::CD6 is a cell surface receptor expressed on the majority of T cells and a subset of B cells. When expressed, CD6 contributes to lymphocyte activation through its extracellular domain 1, while adhesion and cellular migration are related to the extracellular scavenger receptor cysteine-rich domain (SRCR-D)-3 of CD6. Ito...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8423-x
更新日期:2013-07-01 00:00:00
abstract::Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918217
更新日期:1995-01-01 00:00:00
abstract::This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章
doi:10.1007/s12026-007-0047-6
更新日期:2007-01-01 00:00:00
abstract::The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-018-9004-9
更新日期:2018-06-01 00:00:00
abstract::Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:30:3:279
更新日期:2004-01-01 00:00:00
abstract::p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8482-z
更新日期:2014-01-01 00:00:00
abstract::It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8276-8
更新日期:2012-04-01 00:00:00
abstract::Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-017-8926-y
更新日期:2017-08-01 00:00:00
abstract::Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T cell epitopes to antigen-presenting cells. Mice immunized with CP...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8799-5
更新日期:2016-08-01 00:00:00
abstract::In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-011-8237-7
更新日期:2011-10-01 00:00:00
abstract::Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8264-z
更新日期:2012-06-01 00:00:00
abstract::The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786433
更新日期:1998-01-01 00:00:00
abstract::The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09164-2
更新日期:2020-11-03 00:00:00
abstract::Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918222
更新日期:1994-01-01 00:00:00
abstract::It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8017-1
更新日期:2008-01-01 00:00:00
abstract::WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8086-1
更新日期:2009-01-01 00:00:00
abstract::We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8068-3
更新日期:2009-01-01 00:00:00
abstract::The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:33:1:023
更新日期:2005-01-01 00:00:00