Abstract:
:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Aldo-Benson M,Pratt L,Hardwick Jdoi
10.1007/BF02918616subject
Has Abstractpub_date
1992-01-01 00:00:00pages
117-24issue
2eissn
0257-277Xissn
1559-0755journal_volume
11pub_type
杂志文章abstract::Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8768-4
更新日期:2016-08-01 00:00:00
abstract::Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8521-4
更新日期:2014-10-01 00:00:00
abstract::In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:32:1-3:293
更新日期:2005-01-01 00:00:00
abstract::Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:35:3:249
更新日期:2006-01-01 00:00:00
abstract::For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-011-8253-7
更新日期:2011-12-01 00:00:00
abstract::The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:323
更新日期:2002-01-01 00:00:00
abstract::Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8867-x
更新日期:2017-02-01 00:00:00
abstract::In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-011-8237-7
更新日期:2011-10-01 00:00:00
abstract::Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-010-8175-9
更新日期:2011-04-01 00:00:00
abstract::Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8542-z
更新日期:2014-08-01 00:00:00
abstract::Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8084-3
更新日期:2009-01-01 00:00:00
abstract::γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8390-2
更新日期:2013-05-01 00:00:00
abstract::Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09133-9
更新日期:2020-06-01 00:00:00
abstract::Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786471
更新日期:1999-01-01 00:00:00
abstract::Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells. These T cells become activated and, in turn, stimu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:469
更新日期:2003-01-01 00:00:00
abstract::Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02919697
更新日期:1991-01-01 00:00:00
abstract::The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19+CD24hiCD38hi B cells, CD19+CD24hiCD27+ B cells, Th17 cells, and T regulat...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8877-8
更新日期:2017-06-01 00:00:00
abstract::We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8571-7
更新日期:2014-12-01 00:00:00
abstract::Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytoki...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786504
更新日期:1999-01-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02788754
更新日期:1998-01-01 00:00:00
abstract::CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02919132
更新日期:1992-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-019-09112-9
更新日期:2019-12-01 00:00:00
abstract::Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-009-8126-5
更新日期:2010-03-01 00:00:00
abstract::Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8280-z
更新日期:2012-04-01 00:00:00
abstract::The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786443
更新日期:1998-01-01 00:00:00
abstract::The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章
doi:10.1385/IR:36:1:1
更新日期:2006-01-01 00:00:00
abstract::Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:30:1:035
更新日期:2004-01-01 00:00:00
abstract::We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8068-3
更新日期:2009-01-01 00:00:00
abstract::Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:36:1:91
更新日期:2006-01-01 00:00:00
abstract::We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02917584
更新日期:1986-01-01 00:00:00