Abstract：
:We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and secondary humoral immune responses and inhibited, but did not prevent, cellular immune responses. In lupus-prone B/W and BXSB mice, depletion of L3T4+ cells significantly retarded autoimmune disease. Because the L3T4 antigen in mice is homologous to the CD4 antigen in humans, these findings have implications regarding the function of CD4+ T cells and the prospects for using MAb to CD4 as therapeutic agents.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Wofsy D,Seaman WEdoi
10.1007/BF02917584subject
Has Abstractpub_date
1986-01-01 00:00:00pages
97-105issue
2eissn
0257-277Xissn
1559-0755journal_volume
5pub_type
杂志文章abstract：:Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8215-0
更新日期：2011-08-01 00:00:00
abstract：:Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8521-4
更新日期：2014-10-01 00:00:00
abstract：:Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
abstract：:Various multisubunit receptors of the immune system share similarities in structure and induce closely related signal transduction pathways upon ligand binding. Examples include the T cell antigen receptor (TCR), the B cell antigen receptor (BCR), and the high-affinity receptor for immunoglobulin E (Fc epsilon RI). Al...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918171
更新日期：1995-01-01 00:00:00
abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918496
更新日期：1995-01-01 00:00:00
abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8086-1
更新日期：2009-01-01 00:00:00
abstract：:Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T cell epitopes to antigen-presenting cells. Mice immunized with CP...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8799-5
更新日期：2016-08-01 00:00:00
abstract：:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cy...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8976-1
更新日期：2018-02-01 00:00:00
abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:223
更新日期：2002-01-01 00:00:00
abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8996-5
更新日期：2018-06-01 00:00:00
abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8792-z
更新日期：2016-08-01 00:00:00
abstract：:We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8399-6
更新日期：2013-07-01 00:00:00
abstract：:The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1385/IR:36:1:1
更新日期：2006-01-01 00:00:00
abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8785-y
更新日期：2016-08-01 00:00:00
abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9030-7
更新日期：2018-12-01 00:00:00
abstract：:Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918222
更新日期：1994-01-01 00:00:00
abstract：:The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:22:2-3:127
更新日期：2000-01-01 00:00:00
abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:36:1:197
更新日期：2006-01-01 00:00:00
abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-009-8111-z
更新日期：2009-01-01 00:00:00
abstract：:Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0058-3
更新日期：2008-01-01 00:00:00
abstract：:Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8607-z
更新日期：2015-02-01 00:00:00
abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:32:1-3:293
更新日期：2005-01-01 00:00:00
abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8457-0
更新日期：2013-12-01 00:00:00
abstract：:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8528-x
更新日期：2014-08-01 00:00:00
abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-020-09119-7
更新日期：2020-02-01 00:00:00
abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8076-3
更新日期：2008-01-01 00:00:00
abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:1:65
更新日期：2006-01-01 00:00:00
abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8206-1
更新日期：2011-08-01 00:00:00
abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
