Abstract：
:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of the tumor microenvironment in the bone marrow of patients with myeloma. This knowledge has engendered considerable interest in targeting IL-6 for therapeutic purposes, using a variety of antibody- and small-molecule-based therapies. However, despite the early recognition of the importance of IL-6 for myeloma and the steady progress in our knowledge of IL-6 in normal and malignant development of plasma cells, additional efforts will be required to translate the promise of IL-6 as a target for new myeloma therapies into significant clinical benefits for patients with myeloma. This review summarizes published research on the role of IL-6 in myeloma development and describes ongoing efforts by the University of Iowa Myeloma Multidisciplinary Oncology Group to develop new approaches to the design and testing of IL-6-targeted therapies and preventions of MM.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Rosean TR,Tompkins VS,Tricot G,Holman CJ,Olivier AK,Zhan F,Janz Sdoi
10.1007/s12026-014-8528-xsubject
Has Abstractpub_date
2014-08-01 00:00:00pages
188-202issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
59pub_type
杂志文章,评审abstract：:The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...
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pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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更新日期：1986-01-01 00:00:00
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更新日期：2019-12-01 00:00:00
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更新日期：1992-01-01 00:00:00
