Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes.

Abstract:

:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoid the pleiotropic effects observed in mice with germline deletion of SHIP, we have used the Cre-lox system to generate SHIP conditional knockout mice with deletion in specific immune cell populations. In this review we summarize our observations from mice with deletion of SHIP in lymphocyte and macrophage lineages and contrast them with earlier data gathered by the analysis of SHIP null mice.

journal_name

Immunol Res

journal_title

Immunologic research

authors

Leung WH,Tarasenko T,Bolland S

doi

10.1007/s12026-008-8078-1

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

243-51

issue

1-3

eissn

0257-277X

issn

1559-0755

journal_volume

43

pub_type

杂志文章,评审
  • CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.

    abstract::The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-019-09112-9

    authors: Wang N,Liang S,Jin J,Fang L,Ma Q,Wang X,Song Y,Chen L

    更新日期:2019-12-01 00:00:00

  • The role of gamma/delta T cells in immunity to infection and regulation of inflammation.

    abstract::The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/ir:29:1-3:293

    authors: Ziegler HK

    更新日期:2004-01-01 00:00:00

  • Strategies to enhance rituximab anti-tumor activity in the treatment of CD20-positive B-cell neoplasms.

    abstract::Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-009-8121-x

    authors: Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MS

    更新日期:2010-03-01 00:00:00

  • Strategies for differentiating embryonic stem cells (ESC) into insulin-producing cells and development of non-invasive imaging techniques using bioluminescence.

    abstract::Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-007-0070-7

    authors: Chan KM,Raikwar SP,Zavazava N

    更新日期:2007-01-01 00:00:00

  • Regulatory role of CD4+ T cells during the development of contact hypersensitivity responses.

    abstract::Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:24:1:69

    authors: Gorbachev AV,Fairchild RL

    更新日期:2001-01-01 00:00:00

  • Hematopoietic stem cell transplantation from matched unrelated donors in chronic granulomatous disease.

    abstract::We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-008-8068-3

    authors: Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich W

    更新日期:2009-01-01 00:00:00

  • Immunobiology of tumor necrosis factor receptor superfamily.

    abstract::The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:26:1-3:323

    authors: Zhou T,Mountz JD,Kimberly RP

    更新日期:2002-01-01 00:00:00

  • Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus.

    abstract::The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:22:2-3:127

    authors: Krangel MS,McMurry MT,Hernandez-Munain C,Zhong XP,Carabana J

    更新日期:2000-01-01 00:00:00

  • Therapeutic applications of non-myeloablative hematopoietic stem cell transplantation in malignant disease.

    abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:28:1:1

    authors: Hogan WJ,Storb R

    更新日期:2003-01-01 00:00:00

  • Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients.

    abstract::Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plas...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-017-8943-x

    authors: Endreffy I,Bjørklund G,Szerafin L,Chirumbolo S,Urbina MA,Endreffy E

    更新日期:2017-10-01 00:00:00

  • Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases.

    abstract::Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-014-8607-z

    authors: Rojas CM,Borella E,Palma L,Ragozzino S,De Ramón E,Gomez-Huelgas R,Punzi L,Doria A

    更新日期:2015-02-01 00:00:00

  • Complement in central nervous system inflammation.

    abstract::The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:26:1-3:007

    authors: Barnum SR

    更新日期:2002-01-01 00:00:00

  • The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens.

    abstract::Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-007-0076-1

    authors: Connolly SF,Kusner DJ

    更新日期:2007-01-01 00:00:00

  • Silenced suppressor of cytokine signaling 1 (SOCS1) enhances the maturation and antifungal immunity of dendritic cells in response to Candida albicans in vitro.

    abstract::Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-014-8562-8

    authors: Shi D,Li D,Yin Q,Qiu Y,Yan H,Shen Y,Lu G,Liu W

    更新日期:2015-03-01 00:00:00

  • Principles of homeostasis in governing virus activation and latency.

    abstract::The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:21:2-3:219

    authors: Ghazal P,García-Ramírez J,González-Armas JC,Kurz S,Angulo A

    更新日期:2000-01-01 00:00:00

  • The many sounds of T lymphocyte silence.

    abstract::It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initial...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:33:2:135

    authors: Melero I,Arina A,Chen L

    更新日期:2005-01-01 00:00:00

  • Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.

    abstract::Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-015-8768-4

    authors: Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

    更新日期:2016-08-01 00:00:00

  • Tick-borne flaviviruses: dissecting host immune responses and virus countermeasures.

    abstract::The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-008-8065-6

    authors: Robertson SJ,Mitzel DN,Taylor RT,Best SM,Bloom ME

    更新日期:2009-01-01 00:00:00

  • Impact of lymphocyte apoptosis on the innate immune stages of infection.

    abstract::Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-007-0017-z

    authors: Carrero JA,Unanue ER

    更新日期:2007-01-01 00:00:00

  • Complement receptor activity of recombinant porcine CR1-like protein expressed in a eukaryotic system.

    abstract::Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-016-8792-z

    authors: Yin W,Wei X,Jiang J,Fan K,Zhao J,Sun N,Wang Z,Sun Y,Ma H,Zhao X,Li H

    更新日期:2016-08-01 00:00:00

  • Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.

    abstract::During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-012-8301-y

    authors: Alexandropoulos K,Danzl NM

    更新日期:2012-12-01 00:00:00

  • The potential of interleukin-17 to mediate hematopoietic response.

    abstract::It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-012-8276-8

    authors: Krstic A,Mojsilovic S,Jovcic G,Bugarski D

    更新日期:2012-04-01 00:00:00

  • Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers).

    abstract::The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-018-9004-9

    authors: Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

    更新日期:2018-06-01 00:00:00

  • Regulation of the immune response by soybean isoflavones.

    abstract::Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-012-8331-5

    authors: Masilamani M,Wei J,Sampson HA

    更新日期:2012-12-01 00:00:00

  • Expression, regulation and function of human Fc epsilon RII (CD23) antigen.

    abstract::CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/BF02919132

    authors: Sarfati M,Fournier S,Wu CY,Delespesse G

    更新日期:1992-01-01 00:00:00

  • The genetic profiling of preferentially expressed genes in murine splenic CD8α+ dendritic cells.

    abstract::In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-011-8237-7

    authors: Li T,Li WY,Bai HL,Ma HB,Zhang H,Zhu JM,Li XH,Huang HY,Ma YF,Ji XY

    更新日期:2011-10-01 00:00:00

  • Regulation of experimental autoimmune encephalomyelitis by chemokines and chemokine receptors.

    abstract::Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1385/IR:25:2:167

    authors: Elhofy A,Kennedy KJ,Fife BT,Karpus WJ

    更新日期:2002-01-01 00:00:00

  • Increased incidence of autoimmune thyroid disorders in patients with psoriatic arthritis: a longitudinal follow-up study.

    abstract::Contrasting results have been reported about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA). In this study, we pointed to evaluate the incidence of new cases of clinical and subclinical TD in a broad group of patients with PsA versus a control group, matched...

    journal_title:Immunologic research

    pub_type: 杂志文章

    doi:10.1007/s12026-017-8900-8

    authors: Fallahi P,Ferrari SM,Ruffilli I,Elia G,Miccoli M,Sedie AD,Riente L,Antonelli A

    更新日期:2017-06-01 00:00:00

  • Pathogenesis of systemic sclerosis-current concept and emerging treatments.

    abstract::Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/s12026-017-8926-y

    authors: Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

    更新日期:2017-08-01 00:00:00

  • Immune response to staphylococcal superantigens.

    abstract::Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...

    journal_title:Immunologic research

    pub_type: 杂志文章,评审

    doi:10.1007/BF02786471

    authors: Krakauer T

    更新日期:1999-01-01 00:00:00