Abstract:
:Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell killing is a result of direct effects on tumor cell signaling, mAb opsonization of tumor cells also triggers activation of immune responses due to complement activation and engagement of antibody receptors on immune effector cells. In fact, complement has been shown to play an important role in modulating the anti-tumor activity of many mAb through complement-dependent cytotoxicity, antibody-dependent cytotoxicity, and through indirect effects by modulating the tumor microenvironment. Complement activity can have both agonistic and antagonistic effects on these processes. How the balance of such effects impacts on the clinical efficacy of mAb therapy remains unclear. In this review, we discuss the mAbs currently approved for cancer treatment and examine how complement can impact their efficacy with a focus on how this information might be used to improve the clinical efficacy of mAb treatment.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Rogers LM,Veeramani S,Weiner GJdoi
10.1007/s12026-014-8542-zsubject
Has Abstractpub_date
2014-08-01 00:00:00pages
203-10issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
59pub_type
杂志文章,评审abstract::Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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journal_title:Immunologic research
pub_type: 临床试验,杂志文章
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journal_title:Immunologic research
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journal_title:Immunologic research
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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journal_title:Immunologic research
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更新日期:2017-02-01 00:00:00
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