Abstract：
:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research front has been slow and disappointing. In contrast, many valuable concepts emerged from more than 50 years of studying the Friend retrovirus model. This was recently exemplified by the identification of an innate restriction gene, Apobec3, that could promote the retrovirus-specific neutralizing antibody response. Here we review both classical and recent data on humoral immunity against Friend retrovirus infection, and highlight the potential of this model for unraveling novel aspects of the retrovirus-specific antibody response that may guide HIV-1 vaccine development efforts.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Halemano K,Harper MS,Guo K,Li SX,Heilman KJ,Barrett BS,Santiago MLdoi
10.1007/s12026-012-8370-ysubject
Has Abstractpub_date
2013-03-01 00:00:00pages
249-60issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
55pub_type
杂志文章,评审abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title：Immunologic research
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更新日期：2020-02-01 00:00:00
abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title：Immunologic research
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journal_title：Immunologic research
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doi：10.1007/s12026-018-9014-7
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09164-2
更新日期：2020-11-03 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8084-3
更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0004-4
更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Immunologic research
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更新日期：2013-12-01 00:00:00
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journal_title：Immunologic research
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更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2013-12-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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journal_title：Immunologic research
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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