Abstract：
:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal lung function prior to transplantation. At a mean follow-up of 53 months 9 of the 12 patients are alive including 7 of 9 following matched unrelated donor (MUD) transplantation. One patient died from ARDS, another from systemic BK virus infection, the third from complications of chronic graft-versus-host disease. Seven of nine surviving patients have normal lung function now. HSCT from a MUD is an option worth considering when no matched family donor is available. Restricted lung function prior to HSCT does not appear to be a limiting factor for such treatment.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich Wdoi
10.1007/s12026-008-8068-3subject
Has Abstractpub_date
2009-01-01 00:00:00pages
35-41issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
44pub_type
杂志文章abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
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更新日期：2010-03-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2017-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8456-1
更新日期：2013-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
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更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
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更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
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更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786399
更新日期：1997-01-01 00:00:00
