CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.

abstract：:Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...

journal_title：Immunologic research

authors： Dusad A,Duryee MJ,Shaw AT,Klassen LW,Anderson DR,Wang D,Ren K,Gravallese EM,O'Dell JR,Mikuls TR,Thiele GM

更新日期：2014-01-01 00:00:00

abstract：:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...

journal_title：Immunologic research

authors： Ikehara S

更新日期：2007-01-01 00:00:00

abstract：:In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe h...

journal_title：Immunologic research

authors： Wosik J,Suarez-Villagran M,Miller JH Jr,Ghobrial RM,Kloc M

更新日期：2019-02-01 00:00:00

abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...

journal_title：Immunologic research

authors： Virgin HW

更新日期：2005-01-01 00:00:00

abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...

journal_title：Immunologic research

authors： Ciccocioppo R,Racca F,Scudeller L,Piralla A,Formagnana P,Pozzi L,Betti E,Vanoli A,Riboni R,Kruzliak P,Baldanti F,Corazza GR

更新日期：2016-02-01 00:00:00

abstract：:Current approaches for hematopoietic stem cell (HSC) and organ transplantation are limited by donor and host-mediated immune responses to allo-antigens. Application of these therapies is limited by the toxicity of preparative and post-transplant immunosuppressive regimens and a shortage of appropriate HLA-matched dono...

journal_title：Immunologic research

authors： Hacke K,Falahati R,Flebbe-Rehwaldt L,Kasahara N,Gaensler KM

更新日期：2009-01-01 00:00:00

abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...

journal_title：Immunologic research

authors： Yu Y,Sitaraman S,Gewirtz AT

更新日期：2004-01-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...

journal_title：Immunologic research

authors： Sharma R,Das A

更新日期：2018-02-01 00:00:00

abstract：:Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pa...

journal_title：Immunologic research

authors： Wang J,Peng H,Tian J,Ma J,Tang X,Rui K,Tian X,Wang Y,Chen J,Lu L,Xu H,Wang S

更新日期：2016-04-01 00:00:00

abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...

journal_title：Immunologic research

authors： Ghazal P,García-Ramírez J,González-Armas JC,Kurz S,Angulo A

更新日期：2000-01-01 00:00:00

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...

journal_title：Immunologic research

authors： Pestana RM,Domingueti CP,Duarte RC,Fóscolo RB,Reis JS,Rodrigues AM,Martins LB,Sousa LP,Lage DP,Ferreira CN,Ferreira AV,Fernandes AP,Gomes KB

更新日期：2016-08-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum ...

journal_title：Immunologic research

authors： Sternberg Z,Sternberg D,Chichelli T,Drake A,Patel N,Kolb C,Chadha K,Yu J,Hojnacki D

更新日期：2016-04-01 00:00:00

abstract：:It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...

journal_title：Immunologic research

authors： Modiano JF,Johnson LD,Bellgrau D

更新日期：2008-01-01 00:00:00

abstract：:The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. M...

journal_title：Immunologic research

authors： Kobayashi M,Matsumoto Y,Satomi H,Tateishi A,Ohya M,Ito I,Kanno H

更新日期：2020-06-01 00:00:00

abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...

journal_title：Immunologic research

authors： Parker KC,Shields M,DiBrino M,Brooks A,Coligan JE

更新日期：1995-01-01 00:00:00

abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...

journal_title：Immunologic research

authors： Masilamani M,Wei J,Sampson HA

更新日期：2012-12-01 00:00:00

abstract：:Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...

journal_title：Immunologic research

authors： Chan KM,Raikwar SP,Zavazava N

更新日期：2007-01-01 00:00:00

abstract：:The generation and maintenance of B lymphocytes is controlled by biochemical signals transmitted by the B cell antigen receptor(BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs acti...

journal_title：Immunologic research

authors： Khan WN

更新日期：2001-01-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been ...

journal_title：Immunologic research

authors： Bimber B,O'Connor DH

更新日期：2008-01-01 00:00:00

abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...

journal_title：Immunologic research

authors： Santos P,Arumemi F,Park KS,Borghesi L,Milcarek C

更新日期：2011-08-01 00:00:00

abstract：:Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal t...

journal_title：Immunologic research

authors： Del Nagro CJ,Otero DC,Anzelon AN,Omori SA,Kolla RV,Rickert RC

更新日期：2005-01-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...

journal_title：Immunologic research

authors： Khanolkar A,Wilks JD,Liu G,Simpson BM,Caparelli EA,Kirschmann DA,Bergerson J,Fuleihan RL

更新日期：2020-02-01 00:00:00

abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...

journal_title：Immunologic research

authors： Roberts AI,Devadas S,Zhang X,Zhang L,Keegan A,Greeneltch K,Solomon J,Wei L,Das J,Sun E,Liu C,Yuan Z,Zhou JN,Shi Y

更新日期：2003-01-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

journal_title：Immunologic research

authors： Zhang P,Chen BJ,Chao NJ

更新日期：2011-04-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...

journal_title：Immunologic research

authors： Giraldo DM,Hernandez JC,Urcuqui-Inchima S

更新日期：2016-12-01 00:00:00