Abstract:
:The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The number of recognized members of the TNF receptor and ligand superfamily has expanded substantially in the last several years. More important, the biologic function of this group of proteins has been closely associated with the regulation of the immune response and the pathogenesis of autoimmune disease. Thus, the direct targeting of these receptors by either inducing apoptosis or blocking survival of autoimmune T and B cells may be an important therapeutic strategy in the treatment of autoimmune disease. This review summarizes the recent progress in immunobiology of the TNF receptor superfamily and focuses on our studies of three critical family members-FasL/Fas, TNF-related apoptosis-inducing ligand (TRAIL)/TRAIL-Rs, and B lymphocyte stimulator(BLyS)/BLyS-Rs--to demonstrate the therapeutic potential of targeting these receptors for the treatment of autoimmune disease.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Zhou T,Mountz JD,Kimberly RPdoi
10.1385/IR:26:1-3:323subject
Has Abstractpub_date
2002-01-01 00:00:00pages
323-36issue
1-3eissn
0257-277Xissn
1559-0755pii
IR:26:1-3:323journal_volume
26pub_type
杂志文章,评审abstract::Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...
journal_title:Immunologic research
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abstract::The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-s...
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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doi:10.1007/s12026-008-8018-0
更新日期:2008-01-01 00:00:00
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更新日期:2019-10-01 00:00:00
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更新日期:2010-07-01 00:00:00
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