Abstract:
:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracellular signals coupled to the IL-2 receptor and responsible for mediating IL-2 effects in T-cells is far less developed, and the role that protein kinase C (PKC) may play in the various cellular responses to IL-2 receptor activation is unclear. In this article we will discuss IL-2, its receptors, and IL-2 signal transduction in relation to the physiological roles PKC activation may play in IL-2-mediated activation of T-cells and other hematopoietic cells.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Lu Y,Durkin JPdoi
10.1007/BF02786399subject
Has Abstractpub_date
1997-01-01 00:00:00pages
355-74issue
4eissn
0257-277Xissn
1559-0755journal_volume
16pub_type
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pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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更新日期:2020-06-01 00:00:00
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journal_title:Immunologic research
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更新日期:2020-02-01 00:00:00
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更新日期:2002-01-01 00:00:00
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