Abstract:
:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recognized as opposed to 1 of 30 peptides seen when gD was injected in Freund's adjuvant. This has also been seen in the response to local autoantigens when the HSV infection is produced by corneal scarification. Furthermore, analysis of the response to the autoantigen, Golli myelin basic protein (MBP), present in the developing thymus is explored.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Heber-Katz Edoi
10.1007/BF02786433subject
Has Abstractpub_date
1998-01-01 00:00:00pages
83-7issue
1-2eissn
0257-277Xissn
1559-0755journal_volume
17pub_type
杂志文章,评审abstract::Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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abstract::Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8457-0
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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更新日期:2016-08-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09140-w
更新日期:2020-06-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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abstract::In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Immunologic research
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8370-y
更新日期:2013-03-01 00:00:00
abstract::The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
abstract::Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:30:3:279
更新日期:2004-01-01 00:00:00
abstract::Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8628-2
更新日期:2015-03-01 00:00:00
abstract::Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8607-z
更新日期:2015-02-01 00:00:00
abstract::It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8017-1
更新日期:2008-01-01 00:00:00
abstract::Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-018-9046-z
更新日期:2019-02-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8576-2
更新日期:2014-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02917584
更新日期:1986-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
abstract::Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-017-8982-3
更新日期:2018-02-01 00:00:00
abstract::The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...
journal_title:Immunologic research
pub_type: 杂志文章,meta分析
doi:10.1007/s12026-019-09102-x
更新日期:2019-10-01 00:00:00
abstract::Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8265-y
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abstract::For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
abstract::The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章
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更新日期:2006-01-01 00:00:00
abstract::T follicular regulatory (Tfr) cell is a CXCR5+Foxp3+ subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses and modulating the immune environment in the lymph nodes. Studies have shown that the proportion of Tfr cells may increase during acute inflammation. In this study, we inv...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-018-9014-7
更新日期:2018-08-01 00:00:00