Interleukin-8 and its receptor CXCR2 in atherosclerosis.

abstract：:Current approaches for hematopoietic stem cell (HSC) and organ transplantation are limited by donor and host-mediated immune responses to allo-antigens. Application of these therapies is limited by the toxicity of preparative and post-transplant immunosuppressive regimens and a shortage of appropriate HLA-matched dono...

journal_title：Immunologic research

authors： Hacke K,Falahati R,Flebbe-Rehwaldt L,Kasahara N,Gaensler KM

更新日期：2009-01-01 00:00:00

abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...

journal_title：Immunologic research

authors： Lu Y,Durkin JP

更新日期：1997-01-01 00:00:00

abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...

journal_title：Immunologic research

authors： Abdulhaqq SA,Weiner DB

更新日期：2008-01-01 00:00:00

abstract：:The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...

journal_title：Immunologic research

authors： Zhou T,Mountz JD,Kimberly RP

更新日期：2002-01-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...

journal_title：Immunologic research

authors： Pestana RM,Domingueti CP,Duarte RC,Fóscolo RB,Reis JS,Rodrigues AM,Martins LB,Sousa LP,Lage DP,Ferreira CN,Ferreira AV,Fernandes AP,Gomes KB

更新日期：2016-08-01 00:00:00

abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...

journal_title：Immunologic research

authors： Ochs HD

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...

journal_title：Immunologic research

authors： Ghazal P,García-Ramírez J,González-Armas JC,Kurz S,Angulo A

更新日期：2000-01-01 00:00:00

abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

journal_title：Immunologic research

authors： Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

更新日期：2016-08-01 00:00:00

abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...

journal_title：Immunologic research

authors： Shovman O,Gilburd B,Chayat C,Lazar AD,Amital H,Blank M,Bentow C,Mahler M,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...

journal_title：Immunologic research

authors： Bizjak M,Bruck O,Praprotnik S,Dahan S,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...

journal_title：Immunologic research

authors： Peer AJ,Grimm MJ,Zynda ER,Repasky EA

更新日期：2010-03-01 00:00:00

abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...

journal_title：Immunologic research

authors： Wasowska BA

更新日期：2010-07-01 00:00:00

abstract：:The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-s...

journal_title：Immunologic research

authors： Landers CD,Chelvarajan RL,Bondada S

更新日期：2005-01-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...

journal_title：Immunologic research

authors： Levy R

更新日期：2014-05-01 00:00:00

abstract：:Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...

journal_title：Immunologic research

authors： Murphy KM

更新日期：2005-01-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...

journal_title：Immunologic research

authors： Bizzaro N,Tozzoli R,Villalta D

更新日期：2015-02-01 00:00:00

abstract：:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...

journal_title：Immunologic research

authors： Aldo-Benson M,Pratt L,Hardwick J

更新日期：1992-01-01 00:00:00

abstract：:Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...

journal_title：Immunologic research

authors： Fattahi F,Grailer JJ,Jajou L,Zetoune FS,Andjelkovic AV,Ward PA

更新日期：2015-03-01 00:00:00

abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...

journal_title：Immunologic research

authors： Toldi G,Munoz L,Herrmann M,Schett G,Balog A

更新日期：2016-04-01 00:00:00

abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...

journal_title：Immunologic research

authors： Segal Y,Blank M,Shoenfeld Y

更新日期：2018-12-01 00:00:00

abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...

journal_title：Immunologic research

authors： Sharma R,Das A

更新日期：2018-02-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...

journal_title：Immunologic research

authors： Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MS

更新日期：2010-03-01 00:00:00

abstract：:The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...

journal_title：Immunologic research

authors： Barnum SR

更新日期：2002-01-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...

journal_title：Immunologic research

authors： Sarfati M,Fournier S,Wu CY,Delespesse G

更新日期：1992-01-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...

journal_title：Immunologic research

authors： Khanolkar A,Wilks JD,Liu G,Simpson BM,Caparelli EA,Kirschmann DA,Bergerson J,Fuleihan RL

更新日期：2020-02-01 00:00:00

abstract：:In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...

journal_title：Immunologic research

authors： Li T,Li WY,Bai HL,Ma HB,Zhang H,Zhu JM,Li XH,Huang HY,Ma YF,Ji XY

更新日期：2011-10-01 00:00:00