Abstract：
:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting in CD23 overexpression. CD23 is not only an IgE receptor but also a membrane-bound precursor of soluble molecules that still bind IgE (sCD23 or IgE-binding factors). The functions of membrane CD23 are IgE-dependent and vary according to the cell types on which it is expressed. In contrast, sCD23, in addition to being an IgE regulatory molecule, displays multiple cytokine activities that are IgE-independent.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Sarfati M,Fournier S,Wu CY,Delespesse Gdoi
10.1007/BF02919132subject
Has Abstractpub_date
1992-01-01 00:00:00pages
260-72issue
3-4eissn
0257-277Xissn
1559-0755journal_volume
11pub_type
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