Abstract：
:EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinase expressed primarily during the viral lytic replication cycle, and EBNA-1 (Epstein-Barr Virus Nuclear Antigen) expressed during the viral latency cycle respectively were characterized using a laser-printed micro-array ( PEPperprint.com ). IgG response to conserved "A/T hooks" in EBV-encoded proteins such as EBNA-1 and the BALF-2 recombinase related to host DNA-binding proteins including RAG-1 recombinase and histones, and EBV-encoded virokines such as the IL-10 homologue BCRF-1 suggest further directions for clinical research. The author suggests that proteomic "molecular fingerprints" of the immune response to viral proteins shared with human immune response genes are potentially useful in early diagnosis and monitoring of autoantibody production and response to therapy in EBV-related autoimmune syndromes.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Dreyfus DH,Farina A,Farina GAdoi
10.1007/s12026-018-9045-0subject
Has Abstractpub_date
2018-12-01 00:00:00pages
686-695issue
6eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-018-9045-0journal_volume
66pub_type
杂志文章,评审abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8943-x
更新日期：2017-10-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8785-y
更新日期：2016-08-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786484
更新日期：1999-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2019-10-01 00:00:00
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journal_title：Immunologic research
pub_type： 传,历史文章,杂志文章,评审
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更新日期：2014-05-01 00:00:00
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journal_title：Immunologic research
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更新日期：1997-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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