Abstract：
:Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of these components have been identified, and their mechanisms of action elucidated. Understanding these mechanisms is likely to lead in the long-term to ways to intervene in these processes and, therefore, to direct immune response in therapeutically useful directions.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Flavell RAdoi
10.1007/BF02786484subject
Has Abstractpub_date
1999-01-01 00:00:00pages
159-68issue
2-3eissn
0257-277Xissn
1559-0755journal_volume
19pub_type
杂志文章,评审abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8102-0
更新日期：2009-12-01 00:00:00
abstract：:Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章,评审
doi：10.1385/IR:32:1-3:193
更新日期：2005-01-01 00:00:00
abstract：:Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8411-1
更新日期：2013-07-01 00:00:00
abstract：:Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:36:1:91
更新日期：2006-01-01 00:00:00
abstract：:The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:007
更新日期：2002-01-01 00:00:00
abstract：:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoi...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8078-1
更新日期：2009-01-01 00:00:00
abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8628-2
更新日期：2015-03-01 00:00:00
abstract：:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918501
更新日期：1996-01-01 00:00:00
abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8546-8
更新日期：2014-08-01 00:00:00
abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
abstract：:The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8586-0
更新日期：2014-12-01 00:00:00
abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8136-3
更新日期：2010-07-01 00:00:00
abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-010-8187-5
更新日期：2011-04-01 00:00:00
abstract：:It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8017-1
更新日期：2008-01-01 00:00:00
abstract：:The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8130-9
更新日期：2010-03-01 00:00:00
abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:1:65
更新日期：2006-01-01 00:00:00
abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8768-4
更新日期：2016-08-01 00:00:00
abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8265-y
更新日期：2012-09-01 00:00:00
abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919739
更新日期：1991-01-01 00:00:00
abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8823-9
更新日期：2017-02-01 00:00:00
abstract：:An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:24:2:111
更新日期：2001-01-01 00:00:00
abstract：:The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8806-x
更新日期：2016-08-01 00:00:00
abstract：:Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
abstract：:Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-015-8718-1
更新日期：2015-12-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02788754
更新日期：1998-01-01 00:00:00
abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935614
更新日期：1994-01-01 00:00:00
abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:30:2:191
更新日期：2004-01-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8869-8
更新日期：2016-12-01 00:00:00
