Skin deep: from dermal fibroblasts to pancreatic beta cells.

abstract：:Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...

journal_title：Immunologic research

authors： McKenzie BS,Brady JL,Lew AM

更新日期：2004-01-01 00:00:00

abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...

journal_title：Immunologic research

authors： Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich W

更新日期：2009-01-01 00:00:00

abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...

journal_title：Immunologic research

authors： Lu Y,Durkin JP

更新日期：1997-01-01 00:00:00

abstract：:Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...

journal_title：Immunologic research

authors： Zwillich SH,Weiner DB,Williams WV

更新日期：1994-01-01 00:00:00

abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...

journal_title：Immunologic research

authors： Chung E,Kondo M

更新日期：2011-04-01 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...

journal_title：Immunologic research

authors： Reeves E,Elliott T,James E,Edwards CJ

更新日期：2014-12-01 00:00:00

abstract：:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...

journal_title：Immunologic research

authors： Aldo-Benson M,Pratt L,Hardwick J

更新日期：1992-01-01 00:00:00

abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...

journal_title：Immunologic research

authors： Gueta I,Shoenfeld Y,Orbach H

更新日期：2014-12-01 00:00:00

abstract：:Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...

journal_title：Immunologic research

authors： Shi D,Li D,Yin Q,Qiu Y,Yan H,Shen Y,Lu G,Liu W

更新日期：2015-03-01 00:00:00

abstract：:The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...

journal_title：Immunologic research

authors： Abo T,Kawamura T,Watanabe H

更新日期：2005-01-01 00:00:00

abstract：:Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...

journal_title：Immunologic research

authors： Draskovic-Pavlovic B,Vucevic D,Bozic B,Majstorovic I,Colic M

更新日期：2012-04-01 00:00:00

abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...

journal_title：Immunologic research

authors： Kridin K,Shalom G,Comaneshter D,Cohen AD

更新日期：2020-02-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...

journal_title：Immunologic research

authors： Rogers LM,Veeramani S,Weiner GJ

更新日期：2014-08-01 00:00:00

abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...

journal_title：Immunologic research

authors： Livingstone AM,Wilson EB,Ontiveros F,Wang JC

更新日期：2009-12-01 00:00:00

abstract：:The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...

journal_title：Immunologic research

authors： Esposito S,Prada E,Mastrolia MV,Tarantino G,Codecà C,Rigante D

更新日期：2014-12-01 00:00:00

abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...

journal_title：Immunologic research

authors： Cottier F,Pavelka N

更新日期：2012-09-01 00:00:00

abstract：:Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...

journal_title：Immunologic research

authors： Rüthlein J,Heinze G

更新日期：1991-01-01 00:00:00

abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...

journal_title：Immunologic research

authors： Infantino M,Meacci F,Grossi V,Manfredi M,Li Gobbi F,Sarzi-Puttini P,Atzeni F,Benucci M

更新日期：2017-02-01 00:00:00

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...

journal_title：Immunologic research

authors： Stern JN,Keskin DB,Romero V,Zuniga J,Encinales L,Li C,Awad C,Yunis EJ

更新日期：2009-01-01 00:00:00

abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...

journal_title：Immunologic research

authors： Sarfati M,Fournier S,Wu CY,Delespesse G

更新日期：1992-01-01 00:00:00

abstract：:Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and m...

journal_title：Immunologic research

authors： Alijotas-Reig J,Esteve-Valverde E,Gil-Aliberas N,Garcia-Gimenez V

更新日期：2018-02-01 00:00:00

abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

journal_title：Immunologic research

authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

更新日期：2002-01-01 00:00:00

abstract：:Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone ...

journal_title：Immunologic research

authors： da Silva Sacerdote AB,Filgueira NA,de Barros Barreto S,Batista AD,Lopes EP

更新日期：2020-06-01 00:00:00

abstract：:Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...

journal_title：Immunologic research

authors： Aslan M,Freeman BA

更新日期：2002-01-01 00:00:00

abstract：:EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinas...

journal_title：Immunologic research

authors： Dreyfus DH,Farina A,Farina GA

更新日期：2018-12-01 00:00:00

abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...

journal_title：Immunologic research

authors： Wickham S,Ash J,Lane TE,Carr DJ

更新日期：2004-01-01 00:00:00

abstract：:The MHC class II antigen processing pathway provides a mechanism to selectively present peptides generated in the endosomal compartments of antigen presenting cells to CD4+ T cells. Transport of newly synthesized class II molecules to the endosomal pathway requires the function of an accessory protein, invariant chain...

journal_title：Immunologic research

authors： Jensen PE,Weber DA,Thayer WP,Chen X,Dao CT

更新日期：1999-01-01 00:00:00

abstract：:Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...

journal_title：Immunologic research

authors： Chan KM,Raikwar SP,Zavazava N

更新日期：2007-01-01 00:00:00

abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...

journal_title：Immunologic research

authors： O'Rourke DM,Greene MI

更新日期：1998-01-01 00:00:00