Mucosal immunity: overcoming the barrier for induction of proximal responses.

abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...

journal_title：Immunologic research

authors： Shu C,Sun L,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...

journal_title：Immunologic research

authors： Krangel MS,McMurry MT,Hernandez-Munain C,Zhong XP,Carabana J

更新日期：2000-01-01 00:00:00

abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...

journal_title：Immunologic research

authors： Petrovic A,Dorsey M,Miotke J,Shepherd C,Day N

更新日期：2009-01-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...

journal_title：Immunologic research

authors： Heber-Katz E

更新日期：1998-01-01 00:00:00

abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...

journal_title：Immunologic research

authors： Aldo-Benson M,Borel H,Scheiderer-Pratt L,Borel Y

更新日期：1989-01-01 00:00:00

abstract：:The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-s...

journal_title：Immunologic research

authors： Landers CD,Chelvarajan RL,Bondada S

更新日期：2005-01-01 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...

journal_title：Immunologic research

authors： Reeves E,Elliott T,James E,Edwards CJ

更新日期：2014-12-01 00:00:00

abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...

journal_title：Immunologic research

authors： Chung E,Kondo M

更新日期：2011-04-01 00:00:00

abstract：:An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...

journal_title：Immunologic research

authors： Liu MT,Lane TE

更新日期：2001-01-01 00:00:00

abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...

journal_title：Immunologic research

authors： Abdulhaqq SA,Weiner DB

更新日期：2008-01-01 00:00:00

abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...

journal_title：Immunologic research

authors： Roberts AI,Devadas S,Zhang X,Zhang L,Keegan A,Greeneltch K,Solomon J,Wei L,Das J,Sun E,Liu C,Yuan Z,Zhou JN,Shi Y

更新日期：2003-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

journal_title：Immunologic research

authors： Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

更新日期：2017-08-01 00:00:00

abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...

journal_title：Immunologic research

authors： Shovman O,Gilburd B,Chayat C,Lazar AD,Amital H,Blank M,Bentow C,Mahler M,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...

journal_title：Immunologic research

authors： Díaz-Montero CM,Zidan AA,Pallin MF,Anagnostopoulos V,Salem ML,Wieder E,Komanduri K,Montero AJ,Lichtenheld MG

更新日期：2013-12-01 00:00:00

abstract：:The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...

journal_title：Immunologic research

authors： Haynes BF,Sempowski GD,Wells AF,Hale LP

更新日期：2000-01-01 00:00:00

abstract：:Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone ...

journal_title：Immunologic research

authors： da Silva Sacerdote AB,Filgueira NA,de Barros Barreto S,Batista AD,Lopes EP

更新日期：2020-06-01 00:00:00

abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...

journal_title：Immunologic research

authors： Townsend MH,Bennion K,Robison RA,O'Neill KL

更新日期：2020-02-01 00:00:00

abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...

journal_title：Immunologic research

authors： Modell V,Orange JS,Quinn J,Modell F

更新日期：2018-06-01 00:00:00

abstract：:Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...

journal_title：Immunologic research

authors： Fattahi F,Grailer JJ,Jajou L,Zetoune FS,Andjelkovic AV,Ward PA

更新日期：2015-03-01 00:00:00

abstract：:Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled...

journal_title：Immunologic research

authors： Zakaria ZA,Knapp S,Hashem M,Zaghla H,Thursz M,Waked I,Abdelwahab S

更新日期：2019-02-01 00:00:00

abstract：:Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...

journal_title：Immunologic research

authors： Rüthlein J,Heinze G

更新日期：1991-01-01 00:00:00

abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...

journal_title：Immunologic research

authors： Sharif K,Tiosano S,Watad A,Comaneshter D,Cohen AD,Shoenfeld Y,Amital H

更新日期：2018-12-01 00:00:00

abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...

journal_title：Immunologic research

authors： Virgin HW

更新日期：2005-01-01 00:00:00

abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...

journal_title：Immunologic research

authors： Toldi G,Munoz L,Herrmann M,Schett G,Balog A

更新日期：2016-04-01 00:00:00

abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...

journal_title：Immunologic research

authors： Manzar GS,Kim EM,Rotti P,Zavazava N

更新日期：2014-08-01 00:00:00

abstract：:Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating rece...

journal_title：Immunologic research

authors： Hadad U,Martinez O,Krams SM

更新日期：2014-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...

journal_title：Immunologic research

authors： Peer AJ,Grimm MJ,Zynda ER,Repasky EA

更新日期：2010-03-01 00:00:00

abstract：:Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...

journal_title：Immunologic research

authors： Radosevich M,Ono SJ

更新日期：2003-01-01 00:00:00