Abstract：
:The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adult thymus can produce significant numbers of new T cells. Until recently, no assays were available to directly evaluate postnatal thymic function. This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Haynes BF,Sempowski GD,Wells AF,Hale LPdoi
10.1385/IR:22:2-3:253subject
Has Abstractpub_date
2000-01-01 00:00:00pages
253-61issue
2-3eissn
0257-277Xissn
1559-0755pii
IR:22:2-3:253journal_volume
22pub_type
杂志文章,评审abstract：:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02918616
更新日期：1992-01-01 00:00:00
abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...
journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12026-017-8917-z
更新日期：2017-08-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02788754
更新日期：1998-01-01 00:00:00
abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-011-8225-y
更新日期：2011-08-01 00:00:00
abstract：:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:29:1-3:293
更新日期：2004-01-01 00:00:00
abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1007/s12026-007-0047-6
更新日期：2007-01-01 00:00:00
abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:30:2:191
更新日期：2004-01-01 00:00:00
abstract：:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0004-4
更新日期：2007-01-01 00:00:00
abstract：:T follicular regulatory (Tfr) cell is a CXCR5+Foxp3+ subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses and modulating the immune environment in the lymph nodes. Studies have shown that the proportion of Tfr cells may increase during acute inflammation. In this study, we inv...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9014-7
更新日期：2018-08-01 00:00:00
abstract：:Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:31:3:177
更新日期：2005-01-01 00:00:00
abstract：:Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-015-8718-1
更新日期：2015-12-01 00:00:00
abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
abstract：:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoi...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8078-1
更新日期：2009-01-01 00:00:00
abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:1:65
更新日期：2006-01-01 00:00:00
abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8126-5
更新日期：2010-03-01 00:00:00
abstract：:Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0058-3
更新日期：2008-01-01 00:00:00
abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8121-x
更新日期：2010-03-01 00:00:00
abstract：:Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:23:2-3:253
更新日期：2001-01-01 00:00:00
abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8265-y
更新日期：2012-09-01 00:00:00
abstract：:The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1385/IR:36:1:1
更新日期：2006-01-01 00:00:00
abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0017-z
更新日期：2007-01-01 00:00:00
abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09164-2
更新日期：2020-11-03 00:00:00
abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title：Immunologic research
pub_type： 临床试验,杂志文章
doi：10.1007/s12026-017-8967-2
更新日期：2018-02-01 00:00:00
abstract：:Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however,...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-015-8655-z
更新日期：2015-06-01 00:00:00
abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8084-3
更新日期：2009-01-01 00:00:00
abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8823-9
更新日期：2017-02-01 00:00:00
abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8876-9
更新日期：2016-12-01 00:00:00
abstract：:In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8621-1
更新日期：2015-02-01 00:00:00
abstract：:Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytoki...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786504
更新日期：1999-01-01 00:00:00
abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
