Role of cytokines in pulmonary antimicrobial host defense.

abstract：:Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...

journal_title：Immunologic research

authors： Solheim JC,Cook JR,Hansen TH

更新日期：1995-01-01 00:00:00

abstract：:Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...

journal_title：Immunologic research

authors： Chaudhari BR,Murphy RF,Agrawal DK

更新日期：2006-01-01 00:00:00

abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

journal_title：Immunologic research

authors： Carrero JA,Unanue ER

更新日期：2007-01-01 00:00:00

abstract：:It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initial...

journal_title：Immunologic research

authors： Melero I,Arina A,Chen L

更新日期：2005-01-01 00:00:00

abstract：:The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...

journal_title：Immunologic research

authors： Barnum SR

更新日期：2002-01-01 00:00:00

abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...

journal_title：Immunologic research

authors： Infantino M,Meacci F,Grossi V,Manfredi M,Li Gobbi F,Sarzi-Puttini P,Atzeni F,Benucci M

更新日期：2017-02-01 00:00:00

abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...

journal_title：Immunologic research

authors： Parker KC,Shields M,DiBrino M,Brooks A,Coligan JE

更新日期：1995-01-01 00:00:00

abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

journal_title：Immunologic research

authors： Peterson RD

更新日期：2007-01-01 00:00:00

abstract：:Eukaryotic cells perceive and respond to microbes, both pathogenic and commensal, by activation of signaling cascades such as the NF-kappaB pathway. Induction of such pathways leads to the upregulation of a program of gene expression that mediates pro-inflammatory and anti-apoptotic effector proteins. This host respon...

journal_title：Immunologic research

authors： Neish AS

更新日期：2004-01-01 00:00:00

abstract：:Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...

journal_title：Immunologic research

authors： Shi D,Li D,Yin Q,Qiu Y,Yan H,Shen Y,Lu G,Liu W

更新日期：2015-03-01 00:00:00

abstract：:Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can affect immune responses by inducing immune regulation. We recently reported that a single course of treatment with a non-FcR binding anti-CD3 MAb, hOKT3gamm...

journal_title：Immunologic research

authors： Herold KC,Taylor L

更新日期：2003-01-01 00:00:00

abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

journal_title：Immunologic research

authors： Zhou D,Blum JS

更新日期：2004-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...

journal_title：Immunologic research

authors： Himeno K,Hisaeda H

更新日期：1996-01-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...

journal_title：Immunologic research

authors： Peer AJ,Grimm MJ,Zynda ER,Repasky EA

更新日期：2010-03-01 00:00:00

abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...

journal_title：Immunologic research

authors： Berges C,Chatterjee M,Topp MS,Einsele H

更新日期：2016-06-01 00:00:00

abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...

journal_title：Immunologic research

authors： Bizzaro N,Tozzoli R,Villalta D

更新日期：2015-02-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...

journal_title：Immunologic research

authors： Can M,Uygur F,Tanrıverdi H,Acıkgoz B,Alper B,Guven B

更新日期：2016-12-01 00:00:00

abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...

journal_title：Immunologic research

authors： Cronin DC 2nd,Lancki DW,Fitch FW

更新日期：1994-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus that establishes life-long latency and is associated with lymphoproliferative disorders and the development of several malignancies. EBV infection is frequently, but not always, associated with the development of a syndrome termed infectious mononucleosi...

journal_title：Immunologic research

authors： Flaño E,Woodland DL,Blackman MA

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...

journal_title：Immunologic research

authors： Ciccocioppo R,Racca F,Scudeller L,Piralla A,Formagnana P,Pozzi L,Betti E,Vanoli A,Riboni R,Kruzliak P,Baldanti F,Corazza GR

更新日期：2016-02-01 00:00:00

abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...

journal_title：Immunologic research

authors： Modell V,Orange JS,Quinn J,Modell F

更新日期：2018-06-01 00:00:00

abstract：:The initial stages of an immune response are regulated at the level of the cell-surface antigen and Fc receptors. The extracellular portions of these receptors provide immune specificity and determine the nature of the responding effector cells, whereas the intracellular portion transduces signals into the cell and de...

journal_title：Immunologic research

authors： Isakov N

更新日期：1997-02-01 00:00:00

abstract：:Considerable progress has been made in understanding the Fas pathway at the molecular and cellular levels, but fundamental questions about the overall biological role of the Fas pathway remain unresolved. A major question is why lymphoproliferation caused by the lpr mutation of Fas and gld mutation of FasL ligand (Fas...

journal_title：Immunologic research

authors： Hamad AR

更新日期：2010-07-01 00:00:00

abstract：:Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...

journal_title：Immunologic research

authors： Connolly SF,Kusner DJ

更新日期：2007-01-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...

journal_title：Immunologic research

authors： Jongstra-Bilen J,Jongstra J

更新日期：2006-01-01 00:00:00

abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...

journal_title：Immunologic research

authors： Zhang J,Ren M,Zeng H,Guo Y,Zhuang Z,Feng Z,Yan H,Xu M,Liang W,Yang C,Cheng H,Ding H,Yan L

更新日期：2015-06-01 00:00:00