Abstract：
:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan Hdoi
10.1007/s12026-010-8175-9subject
Has Abstractpub_date
2011-04-01 00:00:00pages
109-23issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
49pub_type
杂志文章abstract：:In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...
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更新日期：2017-10-01 00:00:00
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journal_title：Immunologic research
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2018-12-01 00:00:00
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journal_title：Immunologic research
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更新日期：2014-12-01 00:00:00
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journal_title：Immunologic research
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更新日期：2014-01-01 00:00:00
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更新日期：2014-08-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2017-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2018-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
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journal_title：Immunologic research
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786433
更新日期：1998-01-01 00:00:00
