Abstract：
:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cytotoxic. In this study, we examined the T cell receptor (TCR) repertoire and complementarity-determining region 3 sequences of CD28neg. T cells in a melanoma patient with recurrent disease who achieved long-term disease-free status. As a result, the patient's oligoclonal CD8+CD28neg. T cell compartment holds TCRs that are public and specific for Melan-A as well as several public TCRs reported for common viral antigens. While over 80% of his CD8+CD28neg. T cells expressed a cytotoxicity marker, CD57, only 0.01% of CD8+ CD28neg. T cells were positive for Foxp3. In conclusion, our results demonstrate that besides virus-specific also tumor-associated self-antigen targeting T cells accumulate in the CD28neg. compartment of the immunological memory. Since the patient is in ongoing complete remission for more than 9 years, CD8+CD28neg. T cells with the Melan-A-specific TCR might contribute to antitumor immunity in this patient.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Hashimoto H,Sterk M,Schilbach Kdoi
10.1007/s12026-017-8976-1subject
Has Abstractpub_date
2018-02-01 00:00:00pages
79-86issue
1eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-017-8976-1journal_volume
66pub_type
杂志文章abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title：Immunologic research
pub_type： 临床试验,杂志文章
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更新日期：2018-02-01 00:00:00
abstract：:The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...
journal_title：Immunologic research
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doi：10.1007/s12026-015-8769-3
更新日期：2016-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8792-z
更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8995-6
更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8587-z
更新日期：2015-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1995-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:219
更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02788754
更新日期：1998-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786325
更新日期：1997-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02918616
更新日期：1992-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12026-017-8917-z
更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8296-4
更新日期：2012-09-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9044-1
更新日期：2018-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8102-0
更新日期：2009-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8479-7
更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8065-6
更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8331-5
更新日期：2012-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8673-x
更新日期：2016-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:007
更新日期：2002-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0070-7
更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
abstract：:Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918222
更新日期：1994-01-01 00:00:00
abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-017-8926-y
更新日期：2017-08-01 00:00:00
