Abstract：
:This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum levels and the use of disease-modifying drugs (DMDs), and between HMGB1 serum levels and indicators of MS disease severity. HMGB1 serum levels were compared between 96 (23 males) MS patients and 34 age- and gender-matched healthy controls (HCs) using enzyme-linked immunosorbent assays. DMD-naïve MS patients had significantly higher HMGB1 serum levels compared with DMD-treated (P = 0.04) and compared with HCs (P = 0.01). HMGB1 serum levels were not significantly different between total MS patients (DMD-naïve plus DMD-treated) and HCs (P = 0.09). DMD-naïve MS patients in clinical relapse tended to have lower HMGB1 serum levels than clinically stable RRMS patients (P = 0.07). HMGB1 serum levels showed 0.65 area under the curve (95 % CI 0.55-0.95) sensitivity/specificity for MS clinical relapse. The role of HMGB1 in MS disease pathology and DMD modulation of this protein warrant further investigations.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Sternberg Z,Sternberg D,Chichelli T,Drake A,Patel N,Kolb C,Chadha K,Yu J,Hojnacki Ddoi
10.1007/s12026-015-8673-xsubject
Has Abstractpub_date
2016-04-01 00:00:00pages
385-91issue
2eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-015-8673-xjournal_volume
64pub_type
杂志文章abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
abstract：:Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:36:1:91
更新日期：2006-01-01 00:00:00
abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09123-x
更新日期：2020-02-01 00:00:00
abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8571-7
更新日期：2014-12-01 00:00:00
abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8867-x
更新日期：2017-02-01 00:00:00
abstract：:We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8399-6
更新日期：2013-07-01 00:00:00
abstract：:The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8586-0
更新日期：2014-12-01 00:00:00
abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1007/s12026-007-0047-6
更新日期：2007-01-01 00:00:00
abstract：:Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:31:3:177
更新日期：2005-01-01 00:00:00
abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8276-8
更新日期：2012-04-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02788754
更新日期：1998-01-01 00:00:00
abstract：:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:24:1:69
更新日期：2001-01-01 00:00:00
abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8920-4
更新日期：2017-08-01 00:00:00
abstract：:Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02919697
更新日期：1991-01-01 00:00:00
abstract：:Eukaryotic cells perceive and respond to microbes, both pathogenic and commensal, by activation of signaling cascades such as the NF-kappaB pathway. Induction of such pathways leads to the upregulation of a program of gene expression that mediates pro-inflammatory and anti-apoptotic effector proteins. This host respon...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:175
更新日期：2004-01-01 00:00:00
abstract：:Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9046-z
更新日期：2019-02-01 00:00:00
abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8960-9
更新日期：2018-02-01 00:00:00
abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-009-8111-z
更新日期：2009-01-01 00:00:00
abstract：:Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:35:3:249
更新日期：2006-01-01 00:00:00
abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8996-5
更新日期：2018-06-01 00:00:00
abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8068-3
更新日期：2009-01-01 00:00:00
abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8982-3
更新日期：2018-02-01 00:00:00
abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:32:1-3:075
更新日期：2005-01-01 00:00:00
abstract：:Current approaches for hematopoietic stem cell (HSC) and organ transplantation are limited by donor and host-mediated immune responses to allo-antigens. Application of these therapies is limited by the toxicity of preparative and post-transplant immunosuppressive regimens and a shortage of appropriate HLA-matched dono...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8088-z
更新日期：2009-01-01 00:00:00
abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786433
更新日期：1998-01-01 00:00:00
abstract：:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:29:1-3:293
更新日期：2004-01-01 00:00:00
abstract：:Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8689-2
更新日期：2016-04-01 00:00:00
abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8136-3
更新日期：2010-07-01 00:00:00
