Abstract:
:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of cytokine production by gamma/delta T cells. Especially relevant is the apparent paradox that gamma/delta T cells play both pro-inflammatory and antiinflammatory roles in response to infection.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Ziegler HKdoi
10.1385/ir:29:1-3:293subject
Has Abstractpub_date
2004-01-01 00:00:00pages
293-302issue
1-3eissn
0257-277Xissn
1559-0755pii
IR:29:1-3:293journal_volume
29pub_type
杂志文章,评审abstract::Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pa...
journal_title:Immunologic research
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doi:10.1007/s12026-015-8715-4
更新日期:2016-04-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8689-2
更新日期:2016-04-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...
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更新日期:2016-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8683-8
更新日期:2016-04-01 00:00:00
abstract::The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09115-x
更新日期:2020-02-01 00:00:00
abstract::It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8017-1
更新日期:2008-01-01 00:00:00
abstract::We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...
journal_title:Immunologic research
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8018-0
更新日期:2008-01-01 00:00:00
abstract::The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...
journal_title:Immunologic research
pub_type: 杂志文章,meta分析
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更新日期:2019-10-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
abstract::The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-018-9004-9
更新日期:2018-06-01 00:00:00
abstract::In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4%. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5% of the worldwide population, more frequently in patients with multiple sclerosis, rheu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8418-7
更新日期:2013-07-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8562-8
更新日期:2015-03-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:32:1-3:075
更新日期:2005-01-01 00:00:00
abstract::The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:22:2-3:253
更新日期:2000-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8024-2
更新日期:2009-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786484
更新日期:1999-01-01 00:00:00
abstract::Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8528-x
更新日期:2014-08-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786471
更新日期:1999-01-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09140-w
更新日期:2020-06-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:29:1-3:055
更新日期:2004-01-01 00:00:00
abstract::We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8399-6
更新日期:2013-07-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
abstract::Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-011-8206-1
更新日期:2011-08-01 00:00:00
abstract::Limited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccin...
journal_title:Immunologic research
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918253
更新日期:1996-01-01 00:00:00
abstract::Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8296-4
更新日期:2012-09-01 00:00:00
abstract::Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8264-z
更新日期:2012-06-01 00:00:00