Abstract：
:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to antigens deposited in the skin we have studied the development and function of effector and regulatory T cell components of this response. These studies have revealed the effector role of hapten-specific CD8+ T cells in this response. In contrast, hapten-specific CD4+ T cells negatively regulate the magnitude and duration of the response. In this article we propose a model in which the CD4+ T cell compartment regulates the development of effector CD8+ T cells during sensitization for CHS and discuss potential mechanisms that CD4+ T cells might utilize to mediate this regulation.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Gorbachev AV,Fairchild RLdoi
10.1385/IR:24:1:69subject
Has Abstractpub_date
2001-01-01 00:00:00pages
69-77issue
1eissn
0257-277Xissn
1559-0755pii
IR:24:1:69journal_volume
24pub_type
杂志文章,评审abstract：:Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786471
更新日期：1999-01-01 00:00:00
abstract：:Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone ...
journal_title：Immunologic research
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更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786504
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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更新日期：2013-05-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8482-z
更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2013-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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更新日期：2011-04-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：1994-01-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：1997-01-01 00:00:00
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更新日期：2011-12-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2015-02-01 00:00:00
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更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2000-01-01 00:00:00
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更新日期：2015-02-01 00:00:00
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journal_title：Immunologic research
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更新日期：2017-02-01 00:00:00
